Potential anticancer activity of Acetone extracts of Toona cilliata , Seriphium plumosum and Schkuhria pinnata on HeLa cervical cancer cells

• Published in: African health sciences Vol. 21; no. 2; pp. 663 - 672
• Main Authors: Ndlovu, Mxolisi Justice, Bagla, Victor Patrick, Mokgotho, Matlou Phenius, Makgatho, Marema Ephraim, Matsebatlela, Thabe Moss
• Format: Journal Article
• Language: English
• Published: Uganda Makerere Medical School 01-06-2021
• Subjects: Acetone; Antineoplastic Agents, Phytogenic - metabolism; Antineoplastic Agents, Phytogenic - pharmacology; Antioxidants - pharmacology; Female; HeLa Cells - drug effects; Humans; Plant Extracts - metabolism; Plant Extracts - pharmacology; Uterine Cervical Neoplasms - prevention & control; Medicinal plants; antioxidant activity; anticancer activity
• ISSN: 1680-6905; 1729-0503; 1680-6905
• DOI: 10.4314/ahs.v21i2.23

Cervical cancer is common in women in less developed regions of the world. The plant biomolecules can be employed for synergistic activity with chemo- and radiotherapy. This combinations might result in reduced toxicity and increased efficacy of the treatment regimen.
The anti-HeLa cells activity of the acetone extracts of
, T. cilliata and
was assessed using different parameters.
Secondary metabolite detection and antioxidant activity quantification were determined using the DPPH and ferric iron reducing assays. HeLa cell growth inhibition and mechanistics were assessed by employing MTT and Annexin-V flous assays.
Observations revealed the presence of phenolic, flavonoids, tannins steroids and coumarins in all the plants extracts. High amount of total phenolic and flavonoid content were detected in
and
extract had the best DPPH scavenging activity and ferric reducing powers.
Observable concentration dependent cell proliferation inhibition by test materials was exhibited. The leaf extracts from T. cilliata,
and
contain compounds of various polarities with free-radical, antioxidant and anti-cancerous activities that may play a beneficial role in treatment.