Enhancement of itraconazole solubility and release by hot-melt extrusion with Soluplus

Formulation of poorly water-soluble drugs is a significant challenge in the development of oral solid dosage forms. The objective was to investigate the effect of hot-melt extrusion process and formulation variables on the solid state, solubility and release of an ionizable poorly soluble drug, itra...

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Bibliographic Details

Published in:	Journal of drug delivery science and technology Vol. 81; p. 104280
Main Authors:	Darwich, May, Mohylyuk, Valentyn, Kolter, Karl, Bodmeier, Roland, Dashevskiy, Andriy
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-03-2023
Subjects:	Amorphous solid/molecular dispersion Hot-melt extrusion Itraconazole Soluplus Supersaturation Hot-melt extrusion Supersaturation Soluplus Amorphous solid/molecular dispersion Itraconazole
Online Access:	Get full text
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