Solubility of Pholcodine (antitussive drug) in supercritical carbon dioxide: Experimental data and thermodynamic modeling

• Published in: Fluid phase equilibria Vol. 556; p. 113396
• Main Authors: Sodeifian, Gholamhossein, Alwi, Ratna Surya, Razmimanesh, Fariba
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-05-2022
• Subjects: Antitussive drug; Equation of state; Pholcodine; Solid−liquid equilibrium; Solubility; Supercritical carbon dioxide; Solid−liquid equilibrium; Supercritical carbon dioxide; Pholcodine; Equation of state; Solubility; Antitussive drug
• ISSN: 0378-3812; 1879-0224
• DOI: 10.1016/j.fluid.2022.113396

•Solubility of Pholcodine (PHO, antitussive drug) in Sc-CO2 was measured for the first time.•Experiments were conducted on temperatures (308–338 K) and pressures (120–270 bar).•Solubility data were correlated by three density-based models.•Self-consistency of experimental data was confirmed.
Pholcodine (PHO, Antitussive Drug) solubility in supercritical carbon dioxide (Sc-CO2 ) was measured at temperatures of 308, 318, 328, and 338 K and pressures of 120–270 bar. According to the measurements, mole fractions and solubilities of PHO dissolved in Sc-CO2 ranged in 2.06–5.93 × 10−4 and 0.721–4.212 g/L, respectively. Three types of models were employed for correlating experimental results: 1) three existing empirical and semi-empirical models with three and six parameters, 2) the cubic equation of Peng-Robinson with the conventional temperature-dependent and independent mixing rule; and 3) regular solution with Hansen solubility parameter, Reddy-Madras and Alwi et al. models as solid-liquid equilibrium models. Based on the results, all applied models accurately described PHO solubility in Sc-CO2, although Alwi et al. model led to superior results based on AARD (0.29%) and AICc criterion (-647.697).
Graphical Abstract
[Display omitted] .