Four novel HLA class II alleles identified using next‐generation sequencing

Four novel HLA class II alleles identified using next‐generation sequencing

We describe here four novel HLA class II alleles, DPA1*01:33, DPB1*1082:01, DPB1*1144:01, and DQA1*01:45, identified in our laboratory following the implementation of next generation sequencing (NGS) for routine high resolution HLA typing of donors and recipients for solid organ transplant and hemat...

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Bibliographic Details
Published in:HLA : immune response genetics Vol. 98; no. 3; pp. 233 - 234
Main Authors: Gareau, Alison, Abu‐Khader, Ahmad, Yang, Guang, Stamm, Luz, Berka, Noureddine
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Publishing Ltd 01-09-2021
Subjects:
CLASS II
NGS
novel alleles
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Summary:We describe here four novel HLA class II alleles, DPA1*01:33, DPB1*1082:01, DPB1*1144:01, and DQA1*01:45, identified in our laboratory following the implementation of next generation sequencing (NGS) for routine high resolution HLA typing of donors and recipients for solid organ transplant and hematopoetic stem cell transplant. The NGS technology has improved our ability to match at all clinically HLA loci and to facilitate the interpretation of allele specific antibody and eplet matching.
ISSN:2059-2302
2059-2310
DOI:10.1111/tan.14338