The Role of One-Dimensional Model-Generated Inter-Subject Variations in Systemic Properties on Wall Shear Stress Indices of Intracranial Aneurysms

• Published in: IEEE transactions on biomedical engineering Vol. 67; no. 4; pp. 1030 - 1039
• Main Authors: Stevens, Raoul R. F., Donders, Wouter P., Quicken, Sjeng, van de Vosse, Frans N., Mess, Werner H., Delhaas, Tammo, Huberts, Wouter
• Format: Journal Article
• Language: English
• Published: United States IEEE 01-04-2020; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Adaptive generalised polynomial chaos expansion; Aging; Aging (artificial); Aneurysm; Aneurysms; Blood flow; Blood vessels; Boundary conditions; cerebral aneurysms; Computational modeling; Computer simulation; Hemodynamics; One dimensional models; Prediction models; Properties (attributes); Pulse propagation; pulse wave propagation model; Sensitivity analysis; Shear stress; Stiffness; Stress; Three-dimensional displays; Variation; Wall shear stresses; Wave propagation; Waveforms
• ISSN: 0018-9294; 1558-2531
• DOI: 10.1109/TBME.2019.2928416

Variations in systemic properties of the arterial tree, such as aging-induced vessel stiffness, can alter the shape of pressure and flow waveforms. As a consequence, the hemodynamics around a cerebral aneurysm change, and therefore, also the corresponding in- and outlet boundary conditions (BCs) used for three-dimensional (3D) calculations of hemodynamic indices. In this study, we investigate the effects of variations in systemic properties on wall shear stress (WSS) indices of a cerebral aneurysm. We created a virtual patient database by varying systemic properties within physiological ranges. BCs for 3D-CFD simulations were derived using a pulse wave propagation model for each realization of the virtual database. WSS indices were derived from the 3D simulations and their variabilities quantified. Variations in BCs, caused by changes in systemic properties, yielded variabilities in the WSS indices that were of the same order of magnitude as differences in these WSS indices between ruptured and unruptured aneurysms. Sensitivity analysis showed that the systemic properties impacted both in- and outlet BCs simultaneously and altered the WSS indices. We conclude that the influence of variations in patient-specific systemic properties on WSS indices should be evaluated when using WSS indices in multidisciplinary rupture prediction models.