T lymphocyte subsets in chronic uremic patients treated with maintenance hemodialysis

Blood T lymphocyte subsets have been studied using monoclonal antibodies in 10 chronic uremic patients treated with maintenance hemodialysis. Both total T lymphocytes identified by the antibody OKT3, and the helper-inducer T lymphocyte subset identified by the antibody OKT4 were found to be signific...

Full description

Saved in:

Bibliographic Details
Published in:	Biomedicine & pharmacotherapy Vol. 44; no. 1; p. 53
Main Authors:	Morra, L, Ponassi, G A, Gurreri, G, Moccia, F, Mela, G S, Bessone, G
Format:	Journal Article
Language:	English
Published:	France 1990
Subjects:	Adult Female Humans Kidney Diseases - immunology Leukocytes Lymphocytes Male Middle Aged Renal Dialysis T-Lymphocyte Subsets - immunology Uremia - immunology
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Blood T lymphocyte subsets have been studied using monoclonal antibodies in 10 chronic uremic patients treated with maintenance hemodialysis. Both total T lymphocytes identified by the antibody OKT3, and the helper-inducer T lymphocyte subset identified by the antibody OKT4 were found to be significantly lower than normal. The cytotoxic-suppressor T cell subset was only moderately, even if significantly reduced, so that the T4/T8 ratio in uremic patients was significantly lower than normal. These data provide an additional contribution to the interpretation of immunological and hematological deficiencies observed in chronic uremia.
ISSN:	0753-3322
DOI:	10.1016/0753-3322(90)90070-P