Apolipoprotein E1-Hammersmith (Lys146 → Asn;Arg147 → Trp), due to a dinucleotide substitution, is associated with early manifestation of dominant type III hyperlipoproteinaemia

Apolipoprotein E (apoE) is one of the major protein constituents of chylomicron and very low density lipoprotein (VLDL) remnants and plays a central role as a ligand in the receptor-mediated uptake of these particles by the liver. Here we describe a new variant of apoE, apoE1-Hammersmith, which is a...

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Bibliographic Details
Published in:	Atherosclerosis Vol. 124; no. 2; pp. 183 - 189
Main Authors:	Hoffer, Mariëtte J.V, Niththyananthan, Sarojinidevi, Naoumova, Rossitza P, Kibirige, Mohammed S, Frants, Rune R, Havekes, Louis M, Thompson, Gilbert R
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Ireland Ltd 02-08-1996 Elsevier
Subjects:	Adult Anticholesteremic Agents - therapeutic use Apolipoprotein E Apolipoproteins E - blood Apolipoproteins E - drug effects Apolipoproteins E - genetics Biological and medical sciences Child Child, Preschool Cholesterol - blood Cholestyramine Resin - therapeutic use Cysteamine - therapeutic use Dinucleotide Repeats - genetics Disorders of blood lipids. Hyperlipoproteinemia DNA - analysis Dyslipidaemia Electrophoresis Exons Female Fenofibrate Fenofibrate - therapeutic use Genotype Humans Hyperlipoproteinemia Type III - blood Hyperlipoproteinemia Type III - drug therapy Hyperlipoproteinemia Type III - genetics Hypolipidemic Agents - therapeutic use Immunoblotting Male Medical sciences Metabolic diseases Nuclear Family Phenotype Point mutation Point Mutation - genetics Radiation-Protective Agents - therapeutic use Triglycerides - blood Fenofibrate Dyslipidaemia Apolipoprotein E Point mutation Human Metabolic diseases Exploration Lipids Hyperlipoproteinemia
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