A systems approach for decoding mitochondrial retrograde signaling pathways

Mitochondrial dysfunctions activate retrograde signaling from mitochondria to the nucleus. To identify transcription factors and their associated pathways that underlie mitochondrial retrograde signaling, we performed gene expression profiling of the cells engineered to have varying amounts of mitoc...

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Bibliographic Details
Published in:	Science signaling Vol. 6; no. 264; p. rs4
Main Authors:	Chae, Sehyun, Ahn, Byung Yong, Byun, Kyunghee, Cho, Young Min, Yu, Myeong-Hee, Lee, Bonghee, Hwang, Daehee, Park, Kyong Soo
Format:	Journal Article
Language:	English
Published:	United States 26-02-2013
Subjects:	Blotting, Western Cell Nucleus - physiology Gene Expression Profiling Heat-Shock Proteins - metabolism Humans MAP Kinase Kinase 4 - metabolism Mitochondrial Diseases - physiopathology Oxidative Phosphorylation Oxygen Consumption - physiology Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Point Mutation - genetics Reactive Oxygen Species - metabolism Real-Time Polymerase Chain Reaction Retinoid X Receptor alpha - metabolism RNA, Transfer, Leu - genetics Signal Transduction - physiology Systems Biology - methods Transcription Factors - genetics Transcription Factors - metabolism
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