Enhancement by estrogen treatment of -bungarotoxin binding in fetal mouse amygdala cells reaggregated in vitro

Enhancement by estrogen treatment of -bungarotoxin binding in fetal mouse amygdala cells reaggregated in vitro

Dissociated amygdala cells from 17-day-old mouse fetuses were cultivated in a flask for 7 days to form aggregates. In the aggregates there developed typical synaptic structures and [125I]alpha-bungarotoxin binding capacity. An addition of estradiol (100 ng/ml) in the culture medium caused a signific...

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Bibliographic Details
Published in:Neuroscience research Vol. 2; no. 4; p. 211
Main Authors: Arimatsu, Y, Kondo, S, Kojima, M
Format: Journal Article
Language:English
Published: Ireland 01-04-1985
Subjects:
Amygdala - metabolism
Amygdala - ultrastructure
Animals
Bungarotoxins - metabolism
Cell Aggregation
Cells, Cultured
Estradiol - pharmacology
Female
Male
Mice
Mice, Inbred C57BL
Microscopy, Electron
Sex Factors
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Summary:Dissociated amygdala cells from 17-day-old mouse fetuses were cultivated in a flask for 7 days to form aggregates. In the aggregates there developed typical synaptic structures and [125I]alpha-bungarotoxin binding capacity. An addition of estradiol (100 ng/ml) in the culture medium caused a significant increase in the toxin binding capacity. From these results it is concluded that estradiol enhances alpha-bungarotoxin binding capacity in the amygdala by exerting direct effects on the developing amygdala cells.
ISSN:0168-0102
DOI:10.1016/0168-0102(85)90001-X