Organ selectivity of hexahydrosiladifenidol in blocking pre- and postjunctional muscarinic receptors studied in guinea-pig ileum and rat heart
Pre- and postjunctional pA2 values of the muscarinic antagonist hexahydrosiladifenidol were determined with guinea-pig ileum and rat heart. Hexahydrosiladifenidol did not discriminate between pre- and postjunctional receptors within the same organ but was more potent on the ileum (20-80 times) than...
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| Published in: | European journal of pharmacology Vol. 113; no. 1; p. 125 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Netherlands
11-07-1985
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| Abstract | Pre- and postjunctional pA2 values of the muscarinic antagonist hexahydrosiladifenidol were determined with guinea-pig ileum and rat heart. Hexahydrosiladifenidol did not discriminate between pre- and postjunctional receptors within the same organ but was more potent on the ileum (20-80 times) than on the heart. It is concluded that pre- and postjunctional muscarinic receptors in the heart may differ from those in the ileum. |
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| AbstractList | Pre- and postjunctional pA2 values of the muscarinic antagonist hexahydrosiladifenidol were determined with guinea-pig ileum and rat heart. Hexahydrosiladifenidol did not discriminate between pre- and postjunctional receptors within the same organ but was more potent on the ileum (20-80 times) than on the heart. It is concluded that pre- and postjunctional muscarinic receptors in the heart may differ from those in the ileum. |
| Author | Fuder, H Müller, H Kilbinger, H |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/3840090$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Acetylcholine - metabolism Animals Guinea Pigs Heart - drug effects Ileum - drug effects In Vitro Techniques Male Muscle Contraction - drug effects Norepinephrine - metabolism Organ Specificity Parasympatholytics - pharmacology Piperidines - pharmacology Rats Rats, Inbred Strains Receptors, Muscarinic - drug effects |
| Title | Organ selectivity of hexahydrosiladifenidol in blocking pre- and postjunctional muscarinic receptors studied in guinea-pig ileum and rat heart |
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