Dose-related haemodynamic effects and pharmacokinetics of oral nicorandil in patients evaluated for chest pain

We studied the acute haemodynamic dose response of nicorandil, a combined nitrate and potassium channel opener, in patients evaluated for chest pain. Single dose oral nicorandil (5, 10, 20, or 30 mg) or placebo was given to 42 right-heart catheterized patients using a randomized block design. Persis...

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Bibliographic Details
Published in:	International journal of cardiology Vol. 44; no. 3; p. 203
Main Authors:	Arnold, J M, Kowey, P R, Wolf, D L, Jungbluth, G L, Hearron, A E, Luderer, J R
Format:	Journal Article
Language:	English
Published:	Netherlands 01-05-1994
Subjects:	Analysis of Variance Cardiac Catheterization Chest Pain - physiopathology Coronary Disease - physiopathology Dose-Response Relationship, Drug Female Hemodynamics - drug effects Humans Male Middle Aged Niacinamide - administration & dosage Niacinamide - analogs & derivatives Niacinamide - pharmacokinetics Niacinamide - pharmacology Nicorandil Time Factors Vasodilator Agents - administration & dosage Vasodilator Agents - pharmacokinetics Vasodilator Agents - pharmacology
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