Neurological disorders and mitochondria

The brain is highly dependent on mitochondrial energy metabolism. As a result, mitochondrial dysfunction is a central aspect of many adult-onset neurological diseases, including stroke, ALS, Alzheimer's, Huntington's, and Parkinson's diseases. We review here how different mitochondria...

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Bibliographic Details
Published in:	Molecular aspects of medicine Vol. 71; p. 100826
Main Authors:	Cabral-Costa, J V, Kowaltowski, A J
Format:	Journal Article
Language:	English
Published:	England 01-02-2020
Subjects:	Calcium Signaling Energy Metabolism Humans Mitochondria - metabolism Mitochondrial Dynamics Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Oxidative Phosphorylation Oxidative Stress Proteostasis Reactive Oxygen Species - metabolism Mitochondria Reactive oxygen species Calcium Mitophagy Neurodegeneration
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Summary:	The brain is highly dependent on mitochondrial energy metabolism. As a result, mitochondrial dysfunction is a central aspect of many adult-onset neurological diseases, including stroke, ALS, Alzheimer's, Huntington's, and Parkinson's diseases. We review here how different mitochondrial functions, including oxidative phosphorylation, mitochondrial dynamics, oxidant generation, cell death regulation, Ca homeostasis, and proteostasis are involved in these disorders.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0098-2997 1872-9452
DOI:	10.1016/j.mam.2019.10.003