Pharmacological Management of Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome Syndrome: A Proposal of a Treatment Algorithm

• Published in: Journal of clinical rheumatology Vol. 28; no. 2; pp. e545 - e551
• Main Authors: Slouma, Maroua, Bettaieb, Hiba, Rahmouni, Safa, Litaiem, Noureddine, Dhahri, Rim, Gharsallah, Imen, Metoui, Leila, Louzir, Bassem
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 01-03-2022
• Subjects: Acne Vulgaris - diagnosis; Acne Vulgaris - drug therapy; Acquired Hyperostosis Syndrome - diagnosis; Acquired Hyperostosis Syndrome - drug therapy; Algorithms; Humans; Hyperostosis - diagnosis; Hyperostosis - drug therapy; Hyperostosis - etiology; Osteitis - diagnosis; Osteitis - drug therapy; Osteitis - etiology; Synovitis
• ISSN: 1076-1608; 1536-7355
• DOI: 10.1097/RHU.0000000000001740

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic disease with marked clinical and radiological heterogeneity. It is characterized by a combination of dermatological and osteoarticular manifestations. The treatment of SAPHO syndrome is not yet codified. It includes several therapeutic options such as anti-inflammatory drugs, bisphosphonates, antibiotics, conventional disease-modifying antirheumatic drugs, and biological treatment.This article aims to provide an updated review of the different pharmacological options for SAPHO syndrome. We also propose a therapeutic algorithm for the management of this disease.