Preparation and characterization of spray‐dried granulated bioactive glass micron spheres
Owing to its superior bioactivity, biocompatibility, and biodegradability, bioactive glass (BG) has been attracting significant attention within biomedical science fields. However, BG powders with variable particle sizes are required targeting different applications, such as dermal fillers. Thus, in...
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| Published in: | International journal of applied ceramic technology Vol. 18; no. 5; pp. 1743 - 1750 |
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| Format: | Journal Article |
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| Abstract | Owing to its superior bioactivity, biocompatibility, and biodegradability, bioactive glass (BG) has been attracting significant attention within biomedical science fields. However, BG powders with variable particle sizes are required targeting different applications, such as dermal fillers. Thus, in this study, granulated BG powders were prepared via the spray drying and granulation method. Size‐controlled BG micron sphere with diameters of up to tens of microns can be mass‐produced and their phase information, particle morphology, and specific surface area were characterized via X‐ray diffraction, scanning electron microscopy, and nitrogen adsorption/desorption isotherm, respectively. In addition, the in vitro bioactivity was evaluated following Kokubo's protocol, and the formation of a hydroxyapatite (HA) layer after immersion into the simulated body fluid was confirmed via energy‐dispersive and Fourier transform infrared spectroscopy. The cytotoxicity was examined using a 3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenyltetrazolium bromide assay. Finally, the resulting morphologies and corresponding properties are shown, and the related mechanisms are discussed. |
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| AbstractList | Owing to its superior bioactivity, biocompatibility, and biodegradability, bioactive glass (BG) has been attracting significant attention within biomedical science fields. However, BG powders with variable particle sizes are required targeting different applications, such as dermal fillers. Thus, in this study, granulated BG powders were prepared via the spray drying and granulation method. Size‐controlled BG micron sphere with diameters of up to tens of microns can be mass‐produced and their phase information, particle morphology, and specific surface area were characterized via X‐ray diffraction, scanning electron microscopy, and nitrogen adsorption/desorption isotherm, respectively. In addition, the in vitro bioactivity was evaluated following Kokubo's protocol, and the formation of a hydroxyapatite (HA) layer after immersion into the simulated body fluid was confirmed via energy‐dispersive and Fourier transform infrared spectroscopy. The cytotoxicity was examined using a 3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenyltetrazolium bromide assay. Finally, the resulting morphologies and corresponding properties are shown, and the related mechanisms are discussed. |
| Author | Chen, Liu‐Gu Huang, Yu‐Hsuan Chou, Yu‐Jen |
| Author_xml | – sequence: 1 givenname: Liu‐Gu surname: Chen fullname: Chen, Liu‐Gu organization: National Tsing Hua University – sequence: 2 givenname: Yu‐Hsuan surname: Huang fullname: Huang, Yu‐Hsuan organization: National Taiwan University of Science and Technology – sequence: 3 givenname: Yu‐Jen orcidid: 0000-0002-7135-4653 surname: Chou fullname: Chou, Yu‐Jen email: yu-jen.chou@mail.ntust.edu.tw organization: National Taiwan University of Science and Technology |
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| CitedBy_id | crossref_primary_10_3390_ma14113112 crossref_primary_10_3390_jcs8030111 crossref_primary_10_1016_j_ijbiomac_2023_128299 crossref_primary_10_1039_D3RA07472B |
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volume: 65 start-page: 199 year: 2010 ident: e_1_2_7_41_1 article-title: Size‐dependent cytotoxic effects of amorphous silica nanoparticles on langerhans cells publication-title: Pharmazie contributor: fullname: Nabeshi H |
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| SubjectTerms | bioactive glass Biocompatibility Biodegradability Bioglass Biological activity Biomedical materials Body fluids electron microscopy Fourier transforms Granulation Hydroxyapatite In vitro methods and tests micron spheres Morphology Spray drying spray granulation Toxicity |
| Title | Preparation and characterization of spray‐dried granulated bioactive glass micron spheres |
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