Continuous-Flow Chemo and Enzymatic Synthesis of Monoterpenic Esters with Integrated Purification

• Published in: Molecular catalysis Vol. 453; pp. 39 - 46
• Main Authors: Adarme, Carlos A.A., Leão, Raquel A.C., de Souza, Stefania P., Itabaiana, Ivaldo, de Souza, Rodrigo O.M.A., Rezende, Claudia M.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-07-2018
• Subjects: biocatalysis; continuous-flow; geranyl acetate; monoterpenic esters; continuous-flow; monoterpenic esters; biocatalysis; geranyl acetate
• ISSN: 2468-8231; 2468-8231
• DOI: 10.1016/j.mcat.2018.04.007

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•Continuous-flow enzymatic or chemical production of geranyl acetate.•Integrated synthesis and purification in order to deliver high purity products.•Compared batch to continuous protocols under enzymatic and chemical catalysis.
Monoterpenic esters are very important flavor and fragrance compounds due to their organoleptic properties. Despite their importance, many drawbacks are found for the production of monoterpenic esters. Here in we report two different approach’s (chemo and enzymatic) for the continuous production of monoterpenic esters with integrated purification arriving on the desired molecules with high yields (>95%) and short reaction times.