Impaired renal Na(+) retention in the sgk1-knockout mouse

The serum- and glucocorticoid-regulated kinase (sgk1) is induced by mineralocorticoids and, in turn, upregulates heterologously expressed renal epithelial Na(+) channel (ENaC) activity in Xenopus oocytes. Accordingly, Sgk1 is considered to mediate the mineralocorticoid stimulation of renal ENaC acti...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 110; no. 9; pp. 1263 - 1268
Main Authors:	Wulff, Peer, Vallon, Volker, Huang, Dan Yang, Völkl, Harald, Yu, Fang, Richter, Kerstin, Jansen, Martina, Schlünz, Michaela, Klingel, Karin, Loffing, Johannes, Kauselmann, Gunther, Bösl, Michael R, Lang, Florian, Kuhl, Dietmar
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01-11-2002
Subjects:	Animals Biomedical research Blood pressure Epithelial Sodium Channels Female Immediate-Early Proteins Kidney - metabolism Kidney Concentrating Ability Kinases Male Mice Mice, Inbred C57BL Mice, Knockout Mutation Nuclear Proteins Protein-Serine-Threonine Kinases - physiology Sodium - metabolism Sodium Channels - analysis Sodium Chloride, Dietary - administration & dosage
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