Successful Pregnancy and Delivery After Frozen-thawed Embryo Transfer Following the Third Discontinuation of Tyrosine Kinase Inhibitor in a Woman with Chronic Myeloid Leukemia

• Published in: Internal Medicine p. 3322-23
• Main Authors: Takayama, Kosuke, Fujisawa, Shin, Sakuma, Takayuki, Hasegawa, Kodai, Katsuki, Kengo, Akimoto, Masahiro, Matsumura, Ayako, Nakajima, Yuki, Miyazaki, Takuya, Murase, Mariko, Nakajima, Hideaki
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 2024
• Subjects: assisted reproductive technology; chronic myeloid leukemia; pregnancy; tyrosine kinase inhibitor; chronic myeloid leukemia; assisted reproductive technology; tyrosine kinase inhibitor; pregnancy
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.3322-23

Assisted reproductive technology is a viable option for pregnant women with chronic myeloid leukemia. We herein report the case of a patient who underwent successful fertility treatment with frozen embryo preservation at 36 years of age, followed by embryo transfer at 39 years of age, thus resulting in pregnancy and delivery after a third discontinuation of tyrosine kinase inhibitors (TKI). Despite the difficulty of long-term TKI withdrawal, the patient's strong desire for a baby led to a successful pregnancy and delivery with no apparent deformities or abnormalities. Thus, our case highlights the importance of collaboration between reproductive medicine physicians and hematologists.