An integrative model of cancer cell differentiation with immunotherapy

In order to improve cancer treatments, cancer cell differentiation and immunotherapy are the subjects of several studies in different branches of interdisciplinary sciences. In this work, we develop a new population model that integrates other complementary ones, thus emphasizing the relationship be...

Full description

Saved in:

Bibliographic Details
Published in:	Physical biology Vol. 18; no. 6
Main Authors:	Margarit, David H, González, Nadia S, Romanelli, Lilia M, Fendrik, Alejandro J, Scagliotti, Ariel F, Reale, Marcela V
Format:	Journal Article
Language:	English
Published:	England 01-11-2021
Subjects:	Cell Differentiation Humans Immunotherapy Neoplasms - therapy Neoplastic Stem Cells dynamical systems mathematical modelling cancer cell differentiation cancer immunotherapy
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	In order to improve cancer treatments, cancer cell differentiation and immunotherapy are the subjects of several studies in different branches of interdisciplinary sciences. In this work, we develop a new population model that integrates other complementary ones, thus emphasizing the relationship between cancer cells at different differentiation stages and the main immune system cells. For this new system, specific ranges were found where transdifferentiation of differentiated cancer cells can occur. In addition, a specific therapy against cancer stem cells was analysed by simulating cytotoxic cell vaccines. In reference to the latter, the different combinations of parameters that optimize it were studied.
ISSN:	1478-3975
DOI:	10.1088/1478-3975/ac2e72