Transcallosal and endoscopic hybrid approach to a rare entity of pediatric intraventricular tumors—cribriform neuroepithelial tumor: a case report and literature review

• Published in: Child's nervous system Vol. 39; no. 5; pp. 1123 - 1129
• Main Authors: Mete, Emre Bahir, Eray, Halit Anil, Orhan, Ozgur, Zaimoglu, Murat, Ersoz, Cevriye Cansiz, Dogan, Ihsan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-05-2023
• Subjects: Antineoplastic Combined Chemotherapy Protocols; Carcinoma - pathology; Case-based Review; Cerebral Ventricle Neoplasms - diagnostic imaging; Cerebral Ventricle Neoplasms - pathology; Cerebral Ventricle Neoplasms - surgery; Child; Choroid Plexus Neoplasms - diagnostic imaging; Choroid Plexus Neoplasms - surgery; Humans; Infant; Male; Medicine; Medicine & Public Health; Neoplasms, Neuroepithelial - diagnostic imaging; Neoplasms, Neuroepithelial - genetics; Neoplasms, Neuroepithelial - surgery; Neurosciences; Neurosurgery; Intraventricular; Third ventricle; CRINET; Cribriform neuroepithelial tumor
• ISSN: 0256-7040; 1433-0350
• DOI: 10.1007/s00381-023-05897-1

Purpose
Cribriform neuroepithelial tumor (CRINET) is a provisional category of intraventricular tumors, sharing similarities with AT/RTs, and there is a lack of data about its pathology, prognosis, and surgical approaches in the literature. We have been challenged to describe the surgical approach to a rare case of CRINET and describe the intraoperative features since none has been described before. Surgical resection and chemotherapy hold a great importance of favorable prognosis.
Methods
Twenty-month-old male with intraventricular tumor underwent transcallosal intraventricular tumor resection and endoscopic intraventricular second look stages. The tumor was initially considered choroid plexus carcinoma and histopathological results pointed CRINET. The patient also received Ommaya reservoir for intrathecal chemotherapy employment. The patient’s preoperative and postoperative MRI scans and tumor’s pathological features are described with a brief history of the disease in the literature.
Results
Lack of SMARCB1 gene immunoreactivity and presence of cribriform non-rhabdoid trabecular neuroepithelial cells led to the CRINET diagnosis. The surgical technique helped us to approach directly into the third ventricle and perform total resection and intraventricular lavage. The patient recovered without any perioperative complications and is consulted pediatric oncology for further treatment planning.
Conclusion
With our limited knowledge on the matter, our presentation may provide an inside to the course and progress of the CRINET as a very rare tumor and may help to set a basis for future investigations focused on its clinical and pathological features. Long courses of follow-up periods are required for establishing treatment modules and assessing the responses to surgical resection techniques and chemotherapy protocols.