AgI‐promoted one‐pot synthesis of aminoindolizines via sequential Mannich‐Grignard addition and intramolecular cyclization in water

The efficient synthesis of aminoindolizines in ecofriendly water with broad substrate scope from the mild and readily available AgI‐catalyzed one‐pot three‐component reaction of pyridine‐2‐carboxaldehyde, secondary amines, and terminal alkynes proceeds through the sequential Mannich‐Grignard additio...

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Published in:	Journal of heterocyclic chemistry Vol. 58; no. 3; pp. 900 - 904
Main Authors:	Guguloth, Veeranna, Balaboina, Ramesh, Paidakula, Suresh, Thirukovela, Narasimha S., Vadde, Ravinder
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Inc 01-03-2021 Wiley Subscription Services, Inc
Subjects:	Alkynes Amines Substrates Synthesis
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Abstract	The efficient synthesis of aminoindolizines in ecofriendly water with broad substrate scope from the mild and readily available AgI‐catalyzed one‐pot three‐component reaction of pyridine‐2‐carboxaldehyde, secondary amines, and terminal alkynes proceeds through the sequential Mannich‐Grignard addition as well as intramolecular cyclization was reported for the first time.
AbstractList	The efficient synthesis of aminoindolizines in ecofriendly water with broad substrate scope from the mild and readily available AgI‐catalyzed one‐pot three‐component reaction of pyridine‐2‐carboxaldehyde, secondary amines, and terminal alkynes proceeds through the sequential Mannich‐Grignard addition as well as intramolecular cyclization was reported for the first time.
Author	Thirukovela, Narasimha S. Balaboina, Ramesh Paidakula, Suresh Guguloth, Veeranna Vadde, Ravinder
Author_xml	– sequence: 1 givenname: Veeranna surname: Guguloth fullname: Guguloth, Veeranna organization: Kakatiya University – sequence: 2 givenname: Ramesh surname: Balaboina fullname: Balaboina, Ramesh organization: Kakatiya University – sequence: 3 givenname: Suresh surname: Paidakula fullname: Paidakula, Suresh organization: Kakatiya University – sequence: 4 givenname: Narasimha S. surname: Thirukovela fullname: Thirukovela, Narasimha S. email: thirukovelann@gmail.com organization: Chaitanya (Deemed to be University) – sequence: 5 givenname: Ravinder orcidid: 0000-0003-0325-5466 surname: Vadde fullname: Vadde, Ravinder email: ravichemkuc@gmail.com organization: Kakatiya University
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Title	AgI‐promoted one‐pot synthesis of aminoindolizines via sequential Mannich‐Grignard addition and intramolecular cyclization in water
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