Histone Deacetylase 3‐Directed PROTACs Have Anti‐inflammatory Potential by Blocking Polarization of M0‐like into M1‐like Macrophages

Macrophage polarization plays a crucial role in inflammatory processes. The histone deacetylase 3 (HDAC3) has a deacetylase‐independent function that can activate pro‐inflammatory gene expression in lipopolysaccharide‐stimulated M1‐like macrophages and cannot be blocked by traditional small‐molecule...

Full description

Bibliographic Details

Published in:	Angewandte Chemie International Edition Vol. 62; no. 42; p. e202310059
Main Authors:	Zhao, Chunlong, Chen, Shipeng, Chen, Deng, Río‐Bergé, Clàudia, Zhang, Jianqiu, Van Der Wouden, Petra E., Daemen, Toos, Dekker, Frank J.
Format:	Journal Article
Language:	English
Published:	Weinheim Wiley Subscription Services, Inc 16-10-2023
Edition:	International ed. in English
Subjects:	Anti-inflammatory agents Chimeras Cytokines Gene expression Histone deacetylase Histones Inflammation Lipopolysaccharides Macrophages Molecular modelling Polarization Proteolysis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!