From the Cover: Fenretinide, Troglitazone, and Elmiron Add to Weight of Evidence Support for Hemangiosarcoma Mode-of-Action From Studies in Mice

Abstract Pharmaceuticals and chemicals produce hemangiosarcomas (HS) in mice, often by nongenotoxic, proliferative mechanisms. A mode-of-action (MOA) for hemangiosarcoma was proposed based on information presented at an international workshop (Cohen et al., Hemangiosarcoma in rodents: Mode-of-action...

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Bibliographic Details
Published in:	Toxicological sciences Vol. 161; no. 1; pp. 58 - 75
Main Authors:	Cook, Jon C, Obert, Leslie A, Koza-Taylor, Petra, Coskran, Timothy M, Opsahl, Alan C, Ziemek, Daniel, Roy, Marc, Qian, Jessie, Lawton, Michael P, Criswell, Kay A
Format:	Journal Article
Language:	English
Published:	United States Oxford University Press 01-01-2018
Subjects:	Animals Cell Hypoxia - drug effects Cell Proliferation - drug effects Dose-Response Relationship, Drug Endothelial Cells - drug effects Fenretinide - toxicity Hemangiosarcoma - chemically induced Hemangiosarcoma - metabolism Hemangiosarcoma - pathology Macrophage Activation - drug effects Male Mice Neovascularization, Pathologic - chemically induced Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Organ Specificity Pentosan Sulfuric Polyester - toxicity Troglitazone - toxicity mode-of-action hypoxia endothelial cells human relevance hemangiosarcoma
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