VPS33B: let there be α-granules
Comment on Lo et al, page Genesis of platelet dense granules has been studied largely by characterization of molecular defects in patients with syndromes that include dense granule defects. In contrast, little is known about α-granule formation. Lo and colleagues now describe an inherited α-granule...
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| Published in: | Blood Vol. 106; no. 13; pp. 4022 - 4023 |
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| Main Author: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier Inc
15-12-2005
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| Online Access: | Get full text |
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| Summary: | Comment on Lo et al, page
Genesis of platelet dense granules has been studied largely by characterization of molecular defects in patients with syndromes that include dense granule defects. In contrast, little is known about α-granule formation. Lo and colleagues now describe an inherited α-granule defect that demonstrates a requirement for VPS33B in α-granule biogenesis. |
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| ISSN: | 0006-4971 1528-0020 |
| DOI: | 10.1182/blood-2005-09-3928 |