Bone Tissue Condition during Osteosynthesis of a Femoral Shaft Fracture Using Biodegradable Magnesium Implants with an Anticorrosive Coating in Rats with Experimental Osteoporosis

Today, osteoporosis has become a major global health issues. The World Health Organization declares that 320 billion people have osteoporosis now, and more than 1.5 billion osteoporosis traumatic events occur every year. Bones become fragile and fracture risk is high; thus, it is crucial to choose t...

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Published in:	Applied sciences Vol. 12; no. 9; p. 4617
Main Authors:	Maistrovskaia, Yuliya V., Nevzorova, Vera A., Ugay, Liyudmila G., Gnedenkov, Sergey V., Kotsurbei, Evgeny A., Moltyh, Ekaterina A., Kostiv, Roman E., Sinebryukhov, Sergey L.
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 01-05-2022
Subjects:	Angiogenesis Biocompatibility Biodegradability biodegradable implants Biodegradable materials Biodegradation Biomedical materials Bone density Bone growth Bones Coatings Corrosion Corrosion prevention Femur Fractures Global health Hydroxyapatite Laboratory animals Magnesium Magnesium alloys Medical research Metabolism Orthopaedic implants Osteogenesis Osteoporosis Osteosynthesis Patients polytetrafluoroethylene Protective coatings Public health Surgical implants Transplants & implants
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Abstract	Today, osteoporosis has become a major global health issues. The World Health Organization declares that 320 billion people have osteoporosis now, and more than 1.5 billion osteoporosis traumatic events occur every year. Bones become fragile and fracture risk is high; thus, it is crucial to choose the right biodegradable implants in order to minimize reoperations of patients with systemic osteoporosis. This investigation aimed to carry out a morphological assessment of the state of bone tissue with osteosynthesis of a femoral fracture in rats, using a model of osteoporosis with the installation of magnesium alloy implants coated with hydroxyapatite and sealed with polytetrafluoroethylene. According to this study, the indicators of angiogenesis and bone formation in experimental animals were significantly higher when an implant coated with hydroxyapatite sealed with polytetrafluoroethylene was used, compared to an implant coated only with hydroxyapatite and in rats without an implant. Based on the data obtained, it is possible to consider a magnesium implant coated with hydroxyapatite and sealed with polytetrafluoroethylene as a promising material for fracture therapy in patients with reduced bone density.
AbstractList	Today, osteoporosis has become a major global health issues. The World Health Organization declares that 320 billion people have osteoporosis now, and more than 1.5 billion osteoporosis traumatic events occur every year. Bones become fragile and fracture risk is high; thus, it is crucial to choose the right biodegradable implants in order to minimize reoperations of patients with systemic osteoporosis. This investigation aimed to carry out a morphological assessment of the state of bone tissue with osteosynthesis of a femoral fracture in rats, using a model of osteoporosis with the installation of magnesium alloy implants coated with hydroxyapatite and sealed with polytetrafluoroethylene. According to this study, the indicators of angiogenesis and bone formation in experimental animals were significantly higher when an implant coated with hydroxyapatite sealed with polytetrafluoroethylene was used, compared to an implant coated only with hydroxyapatite and in rats without an implant. Based on the data obtained, it is possible to consider a magnesium implant coated with hydroxyapatite and sealed with polytetrafluoroethylene as a promising material for fracture therapy in patients with reduced bone density.
Author	Kostiv, Roman E. Nevzorova, Vera A. Ugay, Liyudmila G. Gnedenkov, Sergey V. Maistrovskaia, Yuliya V. Kotsurbei, Evgeny A. Sinebryukhov, Sergey L. Moltyh, Ekaterina A.
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SubjectTerms	Angiogenesis Biocompatibility Biodegradability biodegradable implants Biodegradable materials Biodegradation Biomedical materials Bone density Bone growth Bones Coatings Corrosion Corrosion prevention Femur Fractures Global health Hydroxyapatite Laboratory animals Magnesium Magnesium alloys Medical research Metabolism Orthopaedic implants Osteogenesis Osteoporosis Osteosynthesis Patients polytetrafluoroethylene Protective coatings Public health Surgical implants Transplants & implants
Title	Bone Tissue Condition during Osteosynthesis of a Femoral Shaft Fracture Using Biodegradable Magnesium Implants with an Anticorrosive Coating in Rats with Experimental Osteoporosis
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