A Wireless Multi-Channel Peripheral Nerve Signal Acquisition System-on-Chip

• Published in: IEEE journal of solid-state circuits Vol. 54; no. 8; pp. 2266 - 2280
• Main Authors: Ng, Kian Ann, Yuan, Chao, Rusly, Astrid, Do, Anh-Tuan, Zhao, Bin, Liu, Shih-Chiang, Peh, Wendy Yen Xian, Thow, Xin Yuan, Voges, Kai, Lee, Sanghoon, Gammad, Gil Gerald Lasam, Leong, Khay-Wai, Ho, John S., Bossi, Silvia, Taverni, Gemma, Cutrone, Annarita, Yen, Shih-Cheng, Xu, Yong Ping
• Format: Journal Article
• Language: English
• Published: New York IEEE 01-08-2019; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Amplifier; Amplifiers; Bandwidths; Capacitors; Circuits; CMOS; Coils; common-mode feedback (CMFB); common-mode rejection ratio (CMRR); Digitization; Electrodes; Error analysis; Impedance measurement; Implants; input common-mode range; Low noise; low power; low voltage; low-noise amplifier; neural prosthesis; neural recording amplifier; Noise; peripheral nerve; peripheral nerve signal; Peripheral nervous system; Power consumption; Prostheses; signal acquisition; Surgical implants; System on chip; Telemetry; Wireless communication
• ISSN: 0018-9200; 1558-173X
• DOI: 10.1109/JSSC.2019.2909158

The adoption of chronic implantable peripheral nerve-based prosthetic devices is currently hampered by the lack of a highly integrated neural signal acquisition system-on-chip (SoC). We report a ten-channel peripheral nervous system (PNS) electroneurogram (ENG) signal acquisition SoC within an implantable package. Requiring only four off-chip capacitors, this SoC can be co-encapsulated with flexible nerve electrodes and a resonant coil antenna to form a 3.4 cm 3 and 3.9 g implantable device for chronic ENG acquisition. This SoC is inductively powered and controlled through a resonant coil at 22 MHz and transmits the digitized neural signal through a near-infrared LED (NIR-LED). Fabricated in 0.18-<inline-formula> <tex-math notation="LaTeX">\mu \text{m} </tex-math></inline-formula> CMOS, each amplifier channel exhibits an input referred noise of 1.9 <inline-formula> <tex-math notation="LaTeX">\mu \text{V}_{\mathbf {rms}} </tex-math></inline-formula> and a noise efficiency factor (NEF) of 4.0 within the signal bandwidth of 5.5 kHz. Each amplifier channel within the SoC is digitized with 10-bit resolution at 17.5 ksps, and the total power consumption (SoC and NIR-LED) is 4.4 mW when the NIR-LED is driven at 3 Mb/s. An electrode impedance measurement circuit with <10% magnitude and <8° angle error for measuring impedances up to 1 <inline-formula> <tex-math notation="LaTeX">\text{M}\Omega </tex-math></inline-formula> is also incorporated in this SoC. This wireless, low noise ENG acquisition SoC package has been validated in vivo while implanted on a rodent to acquire ENG from its sciatic nerve.