Urodynamic Effects of Prostatic Urethral Lift Procedure for Male Voiding Lower Urinary Tract Symptoms

• Published in: Journal of endourology Vol. 35; no. 12; p. 1813
• Main Authors: Muller, Berrend G, Martens, Frank M J, Heesakkers, John P F A, d'Ancona, Frank C H
• Format: Journal Article
• Language: English
• Published: United States 01-12-2021
• Subjects: Aged; Humans; Lower Urinary Tract Symptoms - surgery; Male; Middle Aged; Prostate - surgery; Prostatic Hyperplasia - surgery; Quality of Life; Urinary Bladder; Urinary Bladder Neck Obstruction - surgery; Urodynamics; BPH; urodynamic; prostatic urethral lift; benign prostatic hyperplasia
• ISSN: 1557-900X
• DOI: 10.1089/end.2021.0050

Primary objective is to investigate whether prostatic urethral lift (PUL) results in an improvement of urodynamic parameters that define bladder outlet obstruction (urethral resistance algorithm [urethral resistance factor (URA)], Schäfer grade, detrusor pressure at maximum flow [P
], and detrusor pressure at bladder opening [P
Open]).
Twenty patients (main inclusion criteria: ≥50 years of age, benign prostatic obstruction (BPO), international prostate symptom score (IPSS) ≥13, prostate volume ≤60 mL, and no middle prostate lobe) were enrolled in the study and a PUL was performed. Patients underwent urodynamic investigation and filled out the IPSS and quality of life (QoL) before and after PUL. A paired t-test was used to analyze the results.
The mean age was 68 years (range 55-79), mean prostate volume (TRUS) was 45 mL (range 20-59), and mean prostate-specific antigen was 2.0 μg/L (0.2-4.4). IPSS of the 16 patients reduced significantly (from 22.20 to 14.47,
 = 0.000).
during pressure flow study improved significantly (from 4.5 to 7.2 mL/s,
 = 0.001), no significant difference was found in
during free uroflowmetry. There was no significant difference found in postvoiding residual. URA decreased significantly post-treatment (from 52 to 37 cmH
O,
 = 0.000). The Schäfer obstruction plot decreased significantly (from 3.5 to 2.6,
 = 0.022). Seven patients underwent Greenlight Laser Vaporization of the prostate after the PUL attributable to unsatisfactory results.
PUL has desobstructive effects, but they seem clinically modest. The procedure improves urodynamic parameters as well as QoL in males with lower urinary tract symptoms based on BPO. However, the mechanism how PUL leads to a remarkable symptom relief remains unclear and cannot be explained by the desobstructive mechanisms we observed.