The role of human nucleoside transporters in cellular uptake of 4'-thio-beta-D-arabinofuranosylcytosine and beta-D-arabinosylcytosine

4'-Thio-beta-D-arabinofuranosyl cytosine (TaraC) is in phase I development for treatment of cancer. In human equilibrative nucleoside transporter (hENT) 1-containing CEM cells, initial rates of uptake (10 microM; picomoles per microliter of cell water per second) of [3H]TaraC and [3H]1-beta-D-a...

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Bibliographic Details
Published in:	Molecular pharmacology Vol. 70; no. 1; p. 303
Main Authors:	Clarke, Marilyn L, Damaraju, Vijaya L, Zhang, Jing, Mowles, Delores, Tackaberry, Tracey, Lang, Thach, Smith, Kyla M, Young, James D, Tomkinson, Blake, Cass, Carol E
Format:	Journal Article
Language:	English
Published:	United States 01-07-2006
Subjects:	Animals Arabinonucleosides - metabolism Arabinonucleosides - pharmacokinetics Arabinonucleosides - pharmacology Biological Transport - drug effects Cell Line, Tumor Cell Survival - drug effects Cell Survival - genetics Cytarabine - metabolism Cytarabine - pharmacokinetics Cytarabine - pharmacology Cytidine - analogs & derivatives Cytidine - pharmacology Dose-Response Relationship, Drug Equilibrative-Nucleoside Transporter 2 - genetics Equilibrative-Nucleoside Transporter 2 - physiology Female HeLa Cells Humans Membrane Potentials - physiology Nucleoside Transport Proteins - genetics Nucleoside Transport Proteins - physiology Oocytes - metabolism Oocytes - physiology Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Thioinosine - analogs & derivatives Thioinosine - pharmacology Transfection Tritium Uridine - pharmacokinetics Xenopus laevis
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