Evaluation of Scores to Reflect Toxicity Impact on Quality of Life of Patients With Platinum-Resistant Ovarian Cancer: AURELIA Substudy

• Published in: Journal of the National Comprehensive Cancer Network Vol. 21; no. 5; p. 473
• Main Authors: Lequesne, Justine, Joly, Florence, Peron, Julien, Ray-Coquard, Isabelle, Hardy-Bessard, Anne-Claire, Selle, Frédéric, Berton, Dominique, Follana, Philippe, Fabbro, Michel, Lortholary, Alain, Pujade-Lauraine, Eric, Lefèvre-Arbogast, Sophie, Coquan, Elodie
• Format: Journal Article
• Language: English
• Published: United States 01-05-2023
• Subjects: Bevacizumab - adverse effects; Carcinoma, Ovarian Epithelial; Female; Humans; Ovarian Neoplasms - drug therapy; Quality of Life; adverse events; toxicity score; quality of life; ovarian cancer
• ISSN: 1540-1413
• DOI: 10.6004/jnccn.2022.7101

Current standards for toxicity reporting do not fully capture the impact of adverse events (AEs) on patients' quality of life (QoL). This study aimed to evaluate the association between toxicity and QoL by using toxicity scores that take into account CTCAE grade grouping and AE duration and cumulation.
Analyses were performed on the AURELIA trial dataset, including 361 patients with platinum-resistant ovarian cancer treated with chemotherapy alone or with bevacizumab. Global and physical functioning QoL were issued from the EORTC QoL Questionnaire-Core 30 (QLQ-C30), collected at baseline and 8/9 and 16/18 weeks after treatment initiation. Four toxicity scores were computed: the total number of AEs, multiplied by their grade and not, and the cumulative duration of AEs, weighted by their grade and not. Each score included all AEs or only grade 3/4 nonlaboratory or treatment-related AEs. The relationship between toxicity scores and QoL was assessed through linear mixed regression.
We found that 171 (47.5%) and 43 (11.9%) patients experienced at least one grade 3 or 4 AE, respectively, whereas 113 (31.4%) experienced grade 2 AEs only. Physical QoL was negatively associated with all toxicity scores when computed with all grades of AEs (all P<.01), with a weaker association when treatment-related AEs were considered. Global QoL was negatively associated with toxicity scores computed with nonlaboratory all-grade AEs only (β, -3.42 to -3.13; all P<.01). Degrees of association were lower when considering the AE duration.
In this analysis of patients with platinum-resistant ovarian cancer, toxicity scores based on the cumulative number of AEs, modulated or not by grade, were more effective at predicting QoL changes than those based on AE duration. Toxicity impact on QoL was better reflected when grade 2 AEs were taken into account together with grade 3/4 AEs, whatever their treatment imputability, and when laboratory AEs were excluded.