Evaluation of factor for one-point venous blood sampling method based on the causality model

• Published in: Nippon Hōshasen Gijutsu Gakkai zasshi Vol. 65; no. 10; p. 1378
• Main Authors: Matsutomo, Norikazu, Kobara, Kouichi, Sasaki, Fumie, Watanabe, Haruo, Nagaki, Akio, Mimura, Hiroaki, Onishi, Hideo
• Format: Journal Article
• Language: English; Japanese
• Published: Japan 20-10-2009
• Subjects: Aged; Blood Specimen Collection - methods; Female; Humans; Male; Models, Theoretical; Octanols; Tomography, Emission-Computed, Single-Photon; Veins
• ISSN: 0369-4305
• DOI: 10.6009/jjrt.65.1378

One-point venous blood sampling method (Mimura, et al.) can evaluate the rCBF value with a high degree of accuracy. However, the method is accompanied by complexity of technique because it requires a venous blood Octanol value, and its accuracy is affected by factors of input function. Therefore, we evaluated the factors that are used for input function to determine the accuracy input function and simplify the technique.
The input function which uses the time-dependent brain count of 5 minutes, 15 minutes, and 25 minutes from administration, and the input function in which an objective variable is used as the artery octanol value to exclude the venous blood octanol value are created. Therefore, a correlation between these functions and rCBF value by the MS method is evaluated.
Creation of a high-accuracy input function and simplification of technique are possible. The rCBF value obtained by the input function, the factor of which is a time-dependent brain count of 5 minutes from administration, and the objective variable is artery octanol value, had a high correlation with the MS method (y=0.899x+4.653, r=0.842).