Patterns of peptide synthesis in senescent and presenescent human fibroblasts

Peptide production in senescent and presenescent human foreskin fibroblasts was measured using 2-dimensional polyacrylamide gel electrophoresis. This procedure permits the visualization of a cohort of the major peptides being produced. Among this cohort of over 500 peptides only two were found to di...

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Bibliographic Details
Published in:	Journal of cellular physiology Vol. 98; no. 1; p. 193
Main Authors:	Engelhardt, D L, Lee, G T, Moley, J F
Format:	Journal Article
Language:	English
Published:	United States 01-01-1979
Subjects:	Cell Differentiation Cell Division Cells, Cultured Fibroblasts - cytology Fibroblasts - metabolism Humans Peptide Biosynthesis Time Factors
Online Access:	Get more information
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Summary:	Peptide production in senescent and presenescent human foreskin fibroblasts was measured using 2-dimensional polyacrylamide gel electrophoresis. This procedure permits the visualization of a cohort of the major peptides being produced. Among this cohort of over 500 peptides only two were found to differ in relative amount in that more was being produced in senescent cells. This difference was confirmed by measurements of the relative intensity of the peptide spot. This difference was senescent cell-specific and not due to the differences in rate of growth of senescent and non-senescent cells.
ISSN:	0021-9541
DOI:	10.1002/jcp.1040980121