Comparison of Lipid Profile in Patients With and Without Subclinical Hypothyroidism

• Published in: Curēus (Palo Alto, CA) Vol. 13; no. 8; p. e17301
• Main Authors: Ejaz, Mishal, Kumar, Pardeep, Thakur, Murlidhar, Bachani, Parkash, Naz, Sidra, Lal, Kirshan, Shahid, Wajeeha, Shahid, Simra, Jahangir, Maha, Rizwan, Amber
• Format: Journal Article
• Language: English
• Published: Palo Alto (CA) Cureus 19-08-2021
• Subjects: Cardiology; Endocrinology/Diabetes/Metabolism; Internal Medicine
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.17301

INTRODUCTIONThyroid hormone affects lipid metabolism. Various studies have shown a contradictory relationship between lipid profile (LP) and subclinical hypothyroidism (SCH). Currently, there is a scarcity of regional data on the relationship between LP and SCH. METHODSThis longitudinal study was conducted in the internal medicine and cardiology units of a tertiary care hospital in Pakistan from September 2019 to March 2021. A total of 900 participants, of either gender and between the ages of 40 to 70 years, were enrolled in the study. Blood samples were sent to the laboratory to determine lipid and thyroid parameters. Participants were divided into two groups based on the presence of SCH. RESULTSIn our study, 179 (19.8%) participants had SCH. Total cholesterol (TC) and low-density lipoprotein (LDL) was significantly higher in participants with SCH compared to participants without SCH (228.41 ± 35.21 mg/dL vs. 171.21 ± 30.21 mg/dL; p-value: <0.00001) and (131.65 ± 28.22 mg/dL vs. 89.26 ± 18.52 mg/dL; p-value: <0.0001), respectively. CONCLUSIONIn conclusion, this study found an increased incidence of dyslipidemias in patients with SCH. It is associated with elevated TC and LDL levels, which are risk factors for cardiovascular disease and mortality.