Biological Evaluation of Synthesized Schiff Base-Metal Complexes Derived from Sulfisomidine
Purpose Inflammation characterized by edema, redness, and pain predominantly symptomatizes in diseases like allergies, asthma, and arthritis. Anti-inflammatory drugs like NSAIDs have been used to treat inflammation but reportedly cause severe gastrointestinal problems; therefore, new and safer drugs...
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| Published in: | Journal of pharmaceutical innovation Vol. 17; no. 1; pp. 37 - 45 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Springer US
01-03-2022
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| Abstract | Purpose
Inflammation characterized by edema, redness, and pain predominantly symptomatizes in diseases like allergies, asthma, and arthritis. Anti-inflammatory drugs like NSAIDs have been used to treat inflammation but reportedly cause severe gastrointestinal problems; therefore, new and safer drugs are sought-after for better resolution of diseases. The metal-based drugs have been proved as promising alternatives for some of the currently used drugs. The aim of this study was to evaluate antioxidant, antibacterial, and in vivo and in vitro anti-inflammatory activities of new Schiff base derived metal complexes.
Methods
The antioxidant, antibacterial, and in vivo and in vitro anti-inflammatory activities were performed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), agar well diffusion, paw edema, and egg albumin denaturation methods respectively.
Results
Mn (II) and Co (II) complexes showed 0.65 and 1.91 IC
50
values and other complexes showed compelling ABTS antioxidant activity. Cu (II) and Zn (II) complexes exhibited significant antimicrobial activity against all six bacterial strains as compared with the parent Schiff base ligand.
Conclusion
The in vitro anti-inflammatory activity revealed that all the complexes inhibited inflammation in dose-dependent manner, while in vivo results indicated Ni (II) complex as potential anti-inflammatory agent. Hence our drugs were found to be potent antioxidant, antibacterial, as well as anti-inflammatory agents and might be used to suppress disease severity by inhibiting the inflammation. |
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| AbstractList | Purpose
Inflammation characterized by edema, redness, and pain predominantly symptomatizes in diseases like allergies, asthma, and arthritis. Anti-inflammatory drugs like NSAIDs have been used to treat inflammation but reportedly cause severe gastrointestinal problems; therefore, new and safer drugs are sought-after for better resolution of diseases. The metal-based drugs have been proved as promising alternatives for some of the currently used drugs. The aim of this study was to evaluate antioxidant, antibacterial, and in vivo and in vitro anti-inflammatory activities of new Schiff base derived metal complexes.
Methods
The antioxidant, antibacterial, and in vivo and in vitro anti-inflammatory activities were performed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), agar well diffusion, paw edema, and egg albumin denaturation methods respectively.
Results
Mn (II) and Co (II) complexes showed 0.65 and 1.91 IC
50
values and other complexes showed compelling ABTS antioxidant activity. Cu (II) and Zn (II) complexes exhibited significant antimicrobial activity against all six bacterial strains as compared with the parent Schiff base ligand.
Conclusion
The in vitro anti-inflammatory activity revealed that all the complexes inhibited inflammation in dose-dependent manner, while in vivo results indicated Ni (II) complex as potential anti-inflammatory agent. Hence our drugs were found to be potent antioxidant, antibacterial, as well as anti-inflammatory agents and might be used to suppress disease severity by inhibiting the inflammation. |
| Author | Khan, Huma Mumtaz, Amina Khalid, Maryam Mahmud, Tariq Sadia, Aatika Basra, Muhammad Asim Raza Samra, Malka M. |
| Author_xml | – sequence: 1 givenname: Amina surname: Mumtaz fullname: Mumtaz, Amina organization: Applied Chemistry Research Centre, Pakistan Council of Scientific and Industrial Research Laboratories Complex – sequence: 2 givenname: Tariq surname: Mahmud fullname: Mahmud, Tariq organization: Institute of Chemistry, University of the Punjab – sequence: 3 givenname: Maryam surname: Khalid fullname: Khalid, Maryam organization: Institute of Chemistry, University of the Punjab – sequence: 4 givenname: Huma surname: Khan fullname: Khan, Huma organization: Institute of Chemistry, University of the Punjab – sequence: 5 givenname: Aatika surname: Sadia fullname: Sadia, Aatika organization: Institute of Chemistry, University of the Punjab – sequence: 6 givenname: Malka M. surname: Samra fullname: Samra, Malka M. organization: Institute of Chemistry, University of the Punjab – sequence: 7 givenname: Muhammad Asim Raza orcidid: 0000-0002-4242-0025 surname: Basra fullname: Basra, Muhammad Asim Raza email: asimbasra@gmail.com organization: Institute of Chemistry, University of the Punjab |
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| CitedBy_id | crossref_primary_10_1016_j_inoche_2023_110567 crossref_primary_10_2139_ssrn_4153624 crossref_primary_10_1016_j_jics_2023_101041 crossref_primary_10_1080_00958972_2024_2369911 crossref_primary_10_1016_j_poly_2023_116336 crossref_primary_10_1155_2023_3601764 crossref_primary_10_1007_s11696_023_02917_x |
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| Keywords | Schiff base Antibacterial Sulfisomidine Antioxidant Transition metal complexes Anti-inflammatory |
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| Title | Biological Evaluation of Synthesized Schiff Base-Metal Complexes Derived from Sulfisomidine |
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