Biological Evaluation of Synthesized Schiff Base-Metal Complexes Derived from Sulfisomidine

• Published in: Journal of pharmaceutical innovation Vol. 17; no. 1; pp. 37 - 45
• Main Authors: Mumtaz, Amina, Mahmud, Tariq, Khalid, Maryam, Khan, Huma, Sadia, Aatika, Samra, Malka M., Basra, Muhammad Asim Raza
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-03-2022
• Subjects: Biochemical Engineering; Biomedical and Life Sciences; Biomedicine; Biotechnology; Industrial and Production Engineering; Original Article; Pharmacology/Toxicology; Schiff base; Antibacterial; Sulfisomidine; Antioxidant; Transition metal complexes; Anti-inflammatory
• ISSN: 1872-5120; 1939-8042
• DOI: 10.1007/s12247-020-09476-8

Purpose
Inflammation characterized by edema, redness, and pain predominantly symptomatizes in diseases like allergies, asthma, and arthritis. Anti-inflammatory drugs like NSAIDs have been used to treat inflammation but reportedly cause severe gastrointestinal problems; therefore, new and safer drugs are sought-after for better resolution of diseases. The metal-based drugs have been proved as promising alternatives for some of the currently used drugs. The aim of this study was to evaluate antioxidant, antibacterial, and in vivo and in vitro anti-inflammatory activities of new Schiff base derived metal complexes.
Methods
The antioxidant, antibacterial, and in vivo and in vitro anti-inflammatory activities were performed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), agar well diffusion, paw edema, and egg albumin denaturation methods respectively.
Results
Mn (II) and Co (II) complexes showed 0.65 and 1.91 IC
50
values and other complexes showed compelling ABTS antioxidant activity. Cu (II) and Zn (II) complexes exhibited significant antimicrobial activity against all six bacterial strains as compared with the parent Schiff base ligand.
Conclusion
The in vitro anti-inflammatory activity revealed that all the complexes inhibited inflammation in dose-dependent manner, while in vivo results indicated Ni (II) complex as potential anti-inflammatory agent. Hence our drugs were found to be potent antioxidant, antibacterial, as well as anti-inflammatory agents and might be used to suppress disease severity by inhibiting the inflammation.