A right atrium metastasis of breast cancer after long-term endocrine therapy

• Published in: Annals of translational medicine Vol. 7; no. 22; p. 702
• Main Authors: Xu, Fengrui, Wang, Xiaodi, Jiang, Zefei
• Format: Journal Article
• Language: English
• Published: China AME Publishing Company 01-11-2019
• Subjects: Case Report; breast cancer; next-generation sequencing (NGS); Atrium metastasis
• ISSN: 2305-5839; 2305-5839
• DOI: 10.21037/atm.2019.09.36

We report a case of right atrial metastasis in a 66-year-old female patient with breast cancer. The patient presented with palpitation and dyspnea after long-term endocrine therapy. A large echo-dense mass was found in the right atrium after the examination. In order to relieve the symptoms, the patient underwent a resection of the atrial lesion, and the pathology confirmed that it was metastatic breast cancer. Next-generation sequencing (NGS) of the entire exon was taken to explore the gene expression of the metastatic lesion. Forty-eighty genes were identified with mutations, and the mutations of
and
were considered to be associated with the development and metastasis of breast cancer in this case.