Tetramethyl bisphenol A stimulates proliferation but inhibits fetal Leydig cell function in male rats by targeting estrogen receptor α after in utero exposure

Tetramethyl bisphenol A (TMBPA) is a widely used flame retardant. TMBPA has been a toxic to Leydig cells in puberty, but it remains unclear whether TMBPA has a similar inhibitor effect on fetal Leydig cells (FLCs). This study reported morphological and functional alterations of FLCs in the testes of...

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Bibliographic Details
Published in:	Environmental toxicology Vol. 37; no. 11; pp. 2743 - 2755
Main Authors:	Li, Xueyun, Meng, Fangyan, Ye, Lei, Qiao, Xinyi, Li, Jingjing, Tian, Lili, Su, Ming, Lin, Liben, Ge, Ren‐shan, Wang, Yiyan
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 01-11-2022 Wiley Subscription Services, Inc
Subjects:	AKT protein AKT1 protein AKT2 protein Bisphenol A Cyclin-dependent kinase 2 Enzymatic activity Enzyme activity estrogen receptor α Estrogen receptors Estrogens Exposure fetal Leydig cell Fetuses Flame retardants Intrauterine exposure Leydig cells Males Oestrogens Offspring Phosphorylation Proliferation Proteins Puberty Serum Sex hormones Testosterone tetramethyl bisphenol A
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