Membranes of Herpes Simplex Virus Type-1-Infected Human Corneal Epithelial Cells Are Not Permeabilized to Macromolecules and Therefore Do Not Release IL-1α

Membranes of Herpes Simplex Virus Type-1-Infected Human Corneal Epithelial Cells Are Not Permeabilized to Macromolecules and Therefore Do Not Release IL-1α

Nanogram amounts of the proinflammatory cytokine interleukin-1α (IL-1α) were detected in uninfected cultures of human corneal epithelial cells (HCEC). Although HSV-1 replicated >104-fold in these cells and caused extensive cytopathic effects, virus infection was not accompanied by significant ext...

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Bibliographic Details
Published in:Virology (New York, N.Y.) Vol. 244; no. 1; pp. 74 - 78
Main Authors: Tran, Mau T., Dean, David A., Lausch, Robert N., Oakes, John E.
Format: Journal Article
Language:English
Published: Elsevier Inc 25-04-1998
Online Access:Get full text
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Summary:Nanogram amounts of the proinflammatory cytokine interleukin-1α (IL-1α) were detected in uninfected cultures of human corneal epithelial cells (HCEC). Although HSV-1 replicated >104-fold in these cells and caused extensive cytopathic effects, virus infection was not accompanied by significant extracellular release of IL-1α. Additional studies showed that release of radiolabeled cytosolic proteins from virus-infected HCEC was no greater than that released by mock-infected cells. These findings indicate that HSV-1 infection of HCEC does not result in IL-1α release because newly formed virus progeny can escape infected cells without disrupting cell membranes.
Bibliography:ObjectType-Article-2
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ISSN:0042-6822
1096-0341
DOI:10.1006/viro.1998.9084