Novel 4-(4-substituted-thiazol-2-ylamino)-N-(pyridin-2-yl)-benzenesulfonamides as cytotoxic and radiosensitizing agents

A series of novel 4-(4-substituted-thiazol-2-ylamino)-N-(pyridin-2-yl) benzene-sulfonamides were synthesized and screened for their cytotoxic activity against human breast cancer cell line (MCF-7). Compounds 6, 7, 9, 10, 11 , and 14 displayed significant activity against MCF-7 when compared to doxor...

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Bibliographic Details
Published in:	Archives of pharmacal research Vol. 35; no. 1; pp. 59 - 68
Main Authors:	Ghorab, Mostafa M., Ragab, Fatma A., Heiba, Helmy I., Agha, Hebaallah M., Nissan, Yassin M.
Format:	Journal Article
Language:	English
Published:	Heidelberg Pharmaceutical Society of Korea 2012 대한약학회
Subjects:	Benzenesulfonamides Binding Sites Cell Line, Tumor Crystallography, X-Ray Cytotoxins - chemistry Cytotoxins - pharmacology Doxorubicin - pharmacology Drug Screening Assays, Antitumor Humans Medicine Pharmacology/Toxicology Pharmacy Protein Structure, Secondary Radiation-Sensitizing Agents - chemistry Radiation-Sensitizing Agents - pharmacology Research Article Sulfonamides - chemistry Sulfonamides - pharmacology 약학 Radiosensetizing activities Cytotoxic Sulfonamides Thiazoles
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