Ultrastructural study of calcium shift in ischemic/reperfused rat heart under treatment with dimethylthiourea, diltiazem and amiloride

Among factors underlying reperfusion injury are oxygen free radicals and Ca2+ influx via gated calcium channel or via Na+/H(+)-Na+/Ca2+ exchange which lead to calcium overload. The aim of the study was to ultrastructurally visualize the distribution of Ca2+ and to compare binding of calcium by the s...

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Bibliographic Details
Published in:	Basic research in cardiology Vol. 93; no. 4; pp. 269 - 275
Main Authors:	Czarnowska, E, Karwatowska-Prokopczuk, E, Kurzydlowski, K
Format:	Journal Article
Language:	English
Published:	Germany 01-08-1998
Subjects:	Amiloride - therapeutic use Animals Calcium - metabolism Calcium Channel Blockers - therapeutic use Diltiazem - therapeutic use Drug Therapy, Combination Free Radical Scavengers - therapeutic use Heart - drug effects Hydroxyl Radical - metabolism In Vitro Techniques Male Mitochondria, Heart - metabolism Myocardial Ischemia - metabolism Myocardial Reperfusion Injury - prevention & control Myocardium - metabolism Myocardium - ultrastructure Rats Rats, Wistar Sarcolemma - metabolism Sodium-Hydrogen Exchangers - antagonists & inhibitors Thiourea - analogs & derivatives Thiourea - therapeutic use
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