Thrombocytopenia and coagulation impairment after portacaval shunt in the rat

Thrombocytopenia and coagulation impairment after portacaval shunt in the rat

A study has been performed to evaluate the effect of the portacaval shunt on some coagulation tests in the rats. Thrombocytopenia develops, accompanied by a decrease in the total protein and fibrinogen concentrations. Moreover, the Quick time is lengthened, whereas the partial thromboplastin time is...

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Bibliographic Details
Published in:Haemostasis Vol. 7; no. 1; p. 19
Main Authors: Doni, M G, Vassanelli, P, Bonadiman, L, Avventi, G L
Format: Journal Article
Language:English
Published: Switzerland 1978
Subjects:
Animals
Blood Coagulation
Blood Proteins - metabolism
Female
Fibrinogen - metabolism
Kinetics
Male
Portacaval Shunt, Surgical - adverse effects
Prothrombin Time
Rats
Thrombocytopenia - etiology
Thrombocytopenia - metabolism
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Summary:A study has been performed to evaluate the effect of the portacaval shunt on some coagulation tests in the rats. Thrombocytopenia develops, accompanied by a decrease in the total protein and fibrinogen concentrations. Moreover, the Quick time is lengthened, whereas the partial thromboplastin time is not modified. The maximal amplitude and elasticity of the clot, recorded by thrombelastography, appear reduced, and k is lengthened. The results are discussed.
ISSN:0301-0147
DOI:10.1159/000214228