Fabrication of rifampicin microcapsules with a polylactide shell

Procedure for encapsulation of rifampicin by evaporation of a volatile solvent was developed. An effective stabilizer making it possible to reach a 23% incorporation of the main substance into capsules was selected. The basic microcapsule parameters (particle size distribution, degree of polydispers...

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Bibliographic Details
Published in:	Russian journal of applied chemistry Vol. 86; no. 5; pp. 782 - 786
Main Authors:	Sardushkin, M. V., Kienskaya, K. I., Il’yushenko, E. V., Avramenko, G. V.
Format:	Journal Article
Language:	English
Published:	Boston Springer US 01-05-2013
Subjects:	Chemistry Chemistry and Materials Science Chemistry/Food Science Industrial Chemistry/Chemical Engineering Macromolecular Compounds and Polymeric Materials Encapsulation Rifampicin Electric Double Layer Polylactide Interfacial Tension
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Summary:	Procedure for encapsulation of rifampicin by evaporation of a volatile solvent was developed. An effective stabilizer making it possible to reach a 23% incorporation of the main substance into capsules was selected. The basic microcapsule parameters (particle size distribution, degree of polydispersity, and electrokinetic potential) were determined. The kinetics of rifampicin release from microcapsules was examined.
ISSN:	1070-4272 1608-3296
DOI:	10.1134/S1070427213050285