Novel 1,3-diarylpyrazole acrylamides: synthesis, antiplatelet activity screening, and in silico evaluation studies
( E )-3-[3-(pyridin-4-yl)-1-phenyl-1 H -pyrazole-4-yl]acryl amides were evaluated for their antiplatelet activities. Compounds 4o and 4r were found as active derivatives showing a potent inhibitory activity on the arachidonic acid-induced aggregation, with IC 50 of 20.2 and 30.3 μM, respectively. Co...
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| Published in: | Medicinal chemistry research Vol. 22; no. 12; pp. 5922 - 5933 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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01-12-2013
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| Abstract | (
E
)-3-[3-(pyridin-4-yl)-1-phenyl-1
H
-pyrazole-4-yl]acryl amides were evaluated for their antiplatelet activities. Compounds
4o
and
4r
were found as active derivatives showing a potent inhibitory activity on the arachidonic acid-induced aggregation, with IC
50
of 20.2 and 30.3 μM, respectively. Compounds
4j
,
4k
, and
4u
presented significant inhibitor effect on collagen-induced platelet aggregation (73.1, 82.5, and 86.7 %, respectively). All synthesized compounds demonstrated good drug-likeness and drug-score values in silico evaluations. |
|---|---|
| AbstractList | (
E
)-3-[3-(pyridin-4-yl)-1-phenyl-1
H
-pyrazole-4-yl]acryl amides were evaluated for their antiplatelet activities. Compounds
4o
and
4r
were found as active derivatives showing a potent inhibitory activity on the arachidonic acid-induced aggregation, with IC
50
of 20.2 and 30.3 μM, respectively. Compounds
4j
,
4k
, and
4u
presented significant inhibitor effect on collagen-induced platelet aggregation (73.1, 82.5, and 86.7 %, respectively). All synthesized compounds demonstrated good drug-likeness and drug-score values in silico evaluations. |
| Author | Baytas, Sultan Nacak Ozkan, Yesim Fethi Sahin, M. Inceler, Nazan Unlu, Serdar |
| Author_xml | – sequence: 1 givenname: Sultan Nacak surname: Baytas fullname: Baytas, Sultan Nacak email: sbaytas@gmail.com organization: Division of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University – sequence: 2 givenname: Nazan surname: Inceler fullname: Inceler, Nazan organization: Division of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University – sequence: 3 givenname: Yesim surname: Ozkan fullname: Ozkan, Yesim organization: Department of Biochemistry, Faculty of Pharmacy, Gazi University – sequence: 4 givenname: Serdar surname: Unlu fullname: Unlu, Serdar organization: Division of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, FARGEM (Pharmaceutical Research and Development Center) Inc – sequence: 5 givenname: M. surname: Fethi Sahin fullname: Fethi Sahin, M. organization: Division of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University |
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| Cites_doi | 10.1007/s12039-007-0040-6 10.1146/annurev.med.52.1.161 10.1016/j.jacc.2004.08.070 10.2165/00003495-199550010-00002 10.1161/hc4601.099487 10.1146/annurev.bi.55.070186.000441 10.1136/hrt.53.4.363 10.1210/er.2004-0015 10.1080/10426507.2010.550268 10.1016/0163-7827(89)90002-7 10.1080/09537100120058739 10.3390/molecules14041595 10.2174/0929867043365279 10.1016/S0049-3848(03)00382-7 10.1056/NEJM199201233260406 10.1021/jm00142a006 10.1113/jphysiol.1963.sp007185 10.1007/s11886-999-0022-z 10.1021/jo01104a623 10.1021/jm000942e 10.2478/s11532-009-0023-1 10.1038/nrd1198 10.1016/S1359-6446(05)03584-1 10.1056/NEJM199005313222201 10.1016/S0169-409X(00)00129-0 10.1007/978-3-642-88488-7 10.1021/jm00142a005 10.1111/j.2042-7158.1993.tb05670.x 10.1016/S0022-5347(17)44108-5 10.1055/s-0037-1613290 |
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| Keywords | 1,3-Diarylpyrazoles Acryl amides Arachidonic acid Collagen Antiplatelet activity |
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| References | Stahl (CR27) 1969 Loo, Egan, Vaughan, Marion, Felsen, Weisman (CR20) 1987; 137 Bennett (CR5) 2001; 52 McKee, Sane, Deliargyris (CR22) 2002; 88 CR33 Fuster, Badimon, Badimon, Chesebro (CR14) 1992; 326 CR32 Needleman, Turk, Jakschik, Morrison, Morrison, Lefkowith (CR23) 1986; 55 Brueggemeier, Hackett, Diaz-Cruz (CR8) 2005; 26 Mason, Jacobs, Freedman (CR21) 2005; 46 Born, Cross (CR7) 1963; 168 Lizuka, Akahane, Momose, Nakazawa (CR19) 1981; 24 Badadhe, Chavan, Ghotekar, Mandhane, Joshi, Gill (CR3) 2011; 186 Jackson, Schoenwaelder (CR15) 2003; 2 Baytas, Turan Dural, Özkan, Simsek, Gürsel, Ünlü (CR4) 2012; 36 Jyothi, Rai, Kalluraya (CR16) 2007; 119 Davis, Thomas (CR10) 1985; 53 De Leval, Hanson, David, Masereel, Pirotte, Dogne (CR11) 2004; 11 Kalluraya, Rao, Sujith (CR17) 2008; 17 Tetko (CR30) 2005; 10 Algul, Meric, Polat, Yuksek, Serin (CR1) 2009; 7 Lipinski, Lombardo, Dominy, Feeney (CR18) 2001; 46 Storey (CR28) 2001; 12 Ertl, Rohde, Selzer (CR12) 2000; 43 Patrignani (CR24) 2003; 110 Schros (CR25) 1995; 50 Chu, Teague (CR9) 1958; 23 Escalante, Diaz-Coutino (CR13) 2009; 14 Tanouchi, Kawamura, Ohyama, Kajiwara, Iguchi, Okada, Miyamoto, Taniguchi, Hayashi, Lizuka, Nakazawa (CR29) 1981; 24 Berger (CR6) 1999; 1 Yusuf, Reddy, Ounpuu, Anand (CR34) 2001; 104 Silveira, Paulo, Miranda, Rocha, Freita, Barreiro (CR26) 1993; 45 Arita, Hansaki (CR2) 1989; 28 Trip, Cats, Capelle, Vreeken (CR31) 1990; 322 MH Loo (580_CR20) 1987; 137 PJ Mason (580_CR21) 2005; 46 CC Chu (580_CR9) 1958; 23 B Kalluraya (580_CR17) 2008; 17 IV Tetko (580_CR30) 2005; 10 S Yusuf (580_CR34) 2001; 104 MJ Davis (580_CR10) 1985; 53 E Stahl (580_CR27) 1969 S Baytas (580_CR4) 2012; 36 JS Bennett (580_CR5) 2001; 52 O Algul (580_CR1) 2009; 7 PB Berger (580_CR6) 1999; 1 T Tanouchi (580_CR29) 1981; 24 RW Brueggemeier (580_CR8) 2005; 26 J Escalante (580_CR13) 2009; 14 580_CR32 580_CR33 PV Badadhe (580_CR3) 2011; 186 MD Trip (580_CR31) 1990; 322 F Storey (580_CR28) 2001; 12 SA McKee (580_CR22) 2002; 88 P Patrignani (580_CR24) 2003; 110 K Schros (580_CR25) 1995; 50 IAFB Silveira (580_CR26) 1993; 45 H Arita (580_CR2) 1989; 28 CA Lipinski (580_CR18) 2001; 46 P Ertl (580_CR12) 2000; 43 SP Jackson (580_CR15) 2003; 2 V Fuster (580_CR14) 1992; 326 X Leval De (580_CR11) 2004; 11 G Born (580_CR7) 1963; 168 K Lizuka (580_CR19) 1981; 24 C Jyothi (580_CR16) 2007; 119 P Needleman (580_CR23) 1986; 55 |
| References_xml | – volume: 119 start-page: 299 year: 2007 end-page: 302 ident: CR16 article-title: Environmentally benign synthesis of sydnone containing 1,3,4-thiadiazines under microwave and solvent free conditions publication-title: J Chem Sci doi: 10.1007/s12039-007-0040-6 contributor: fullname: Kalluraya – volume: 52 start-page: 161 year: 2001 end-page: 184 ident: CR5 article-title: Novel platelet inhibitors publication-title: Annu Rev Med doi: 10.1146/annurev.med.52.1.161 contributor: fullname: Bennett – volume: 46 start-page: 986 year: 2005 end-page: 993 ident: CR21 article-title: Aspirin resistance and atherothrombotic disease publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2004.08.070 contributor: fullname: Freedman – volume: 50 start-page: 7 year: 1995 end-page: 28 ident: CR25 article-title: Antiplatelet drugs: a comparative review publication-title: Drugs doi: 10.2165/00003495-199550010-00002 contributor: fullname: Schros – volume: 104 start-page: 2746 year: 2001 end-page: 2753 ident: CR34 article-title: Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization publication-title: Circulation doi: 10.1161/hc4601.099487 contributor: fullname: Anand – ident: CR33 – volume: 55 start-page: 69 year: 1986 end-page: 102 ident: CR23 article-title: Arachidonic acid metabolism publication-title: Annu Rev Biochem doi: 10.1146/annurev.bi.55.070186.000441 contributor: fullname: Lefkowith – volume: 53 start-page: 363 year: 1985 end-page: 373 ident: CR10 article-title: Plaque fissuring-the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina publication-title: Br Heart J doi: 10.1136/hrt.53.4.363 contributor: fullname: Thomas – volume: 26 start-page: 331 year: 2005 end-page: 345 ident: CR8 article-title: Aromatase inhibitors in the treatment of breast cancer publication-title: Endocr Rev doi: 10.1210/er.2004-0015 contributor: fullname: Diaz-Cruz – volume: 186 start-page: 2021 year: 2011 end-page: 2032 ident: CR3 article-title: Synthesis, characterization, and biological screening of some novel thiazolidin-4-one and alpha-aminophosphonate derivatives publication-title: Phosphorus Sulfur and Silicon Relat Elem doi: 10.1080/10426507.2010.550268 contributor: fullname: Gill – volume: 36 start-page: 367 year: 2012 end-page: 382 ident: CR4 article-title: Synthesis, anti-inflammatory, antiplatelet and in silico evaluations of (E)-3-(3-(2,3-dihydro-3-methyl-2-oxo-3H-benzoxazole-6-yl)-1-phenyl-1H-pyrazole-4-yl)acrylamides publication-title: Turk J Chem contributor: fullname: Ünlü – volume: 28 start-page: 273 year: 1989 end-page: 301 ident: CR2 article-title: Thromboxane A2: its generation and role in platelet activation publication-title: Prog Lipid Res doi: 10.1016/0163-7827(89)90002-7 contributor: fullname: Hansaki – volume: 12 start-page: 197 year: 2001 end-page: 209 ident: CR28 article-title: The P2Y12 receptor as a therapeutic target in cardiovascular disease publication-title: Platelets doi: 10.1080/09537100120058739 contributor: fullname: Storey – volume: 14 start-page: 1595 year: 2009 end-page: 1604 ident: CR13 article-title: Synthesis of c-nitro aliphaticmethyl esters via Michael additions promoted by microwave irradiation publication-title: Molecules doi: 10.3390/molecules14041595 contributor: fullname: Diaz-Coutino – volume: 137 start-page: 571 year: 1987 end-page: 576 ident: CR20 article-title: The effect of the thromboxane A2 synthesis inhibitor OKY-046 on renal function in rabbits following release of unilateral ureteral obstruction publication-title: J Urol contributor: fullname: Weisman – volume: 11 start-page: 1243 year: 2004 end-page: 1252 ident: CR11 article-title: New developments on thromboxane and prostacyclin modulators. Part II: prostacyclin modulators publication-title: Curr Med Chem doi: 10.2174/0929867043365279 contributor: fullname: Dogne – volume: 110 start-page: 281 year: 2003 end-page: 286 ident: CR24 article-title: Aspirin insensitive eicosanoid biosynthesis in cardiovascular disease publication-title: Thromb Res doi: 10.1016/S0049-3848(03)00382-7 contributor: fullname: Patrignani – volume: 17 start-page: 359 year: 2008 end-page: 362 ident: CR17 article-title: Microwave assisted one-pot synthesis of some 2,5-disubstituted 1,3,4-oxadiazoles publication-title: Indian J Heterocycl Chem contributor: fullname: Sujith – volume: 326 start-page: 242 year: 1992 end-page: 250 ident: CR14 article-title: The pathogenesis of coronary artery disease and the acute coronary syndromes (1) publication-title: N Engl J Med doi: 10.1056/NEJM199201233260406 contributor: fullname: Chesebro – volume: 24 start-page: 1149 year: 1981 end-page: 1155 ident: CR29 article-title: Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives publication-title: J Med Chem doi: 10.1021/jm00142a006 contributor: fullname: Nakazawa – volume: 168 start-page: 178 year: 1963 end-page: 195 ident: CR7 article-title: The aggregation of blood platelet publication-title: J Physiol doi: 10.1113/jphysiol.1963.sp007185 contributor: fullname: Cross – volume: 88 start-page: 711 year: 2002 end-page: 715 ident: CR22 article-title: Aspirin resistance in cardiovascular disease: a review of prevalence, mechanisms, and clinical significance publication-title: Thromb Haemost contributor: fullname: Deliargyris – volume: 1 start-page: 192 year: 1999 end-page: 198 ident: CR6 article-title: The thienopyridines in coronary artery disease publication-title: Curr Cardiol Rep doi: 10.1007/s11886-999-0022-z contributor: fullname: Berger – volume: 23 start-page: 1578 year: 1958 ident: CR9 article-title: 4-Pyridylhydantoins publication-title: J Org Chem doi: 10.1021/jo01104a623 contributor: fullname: Teague – volume: 43 start-page: 3714 year: 2000 end-page: 3717 ident: CR12 article-title: Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties publication-title: J Med Chem doi: 10.1021/jm000942e contributor: fullname: Selzer – volume: 7 start-page: 337 year: 2009 end-page: 342 ident: CR1 article-title: Comparative studies on conventional and microwave-assisted synthesis of a series of 2,4-di and 2,3,4-trisubstituted benzimidazo[1,2-a]pyrimidines and their antimicrobial activities publication-title: Cent Eur J Chem doi: 10.2478/s11532-009-0023-1 contributor: fullname: Serin – ident: CR32 – volume: 2 start-page: 775 year: 2003 end-page: 789 ident: CR15 article-title: Antiplatelet therapy: in search of the ‘magic bullet’ publication-title: Nat Rev Drug Discov doi: 10.1038/nrd1198 contributor: fullname: Schoenwaelder – volume: 10 start-page: 1497 year: 2005 end-page: 1500 ident: CR30 article-title: Computing chemistry on the web publication-title: Drug Discov Today doi: 10.1016/S1359-6446(05)03584-1 contributor: fullname: Tetko – volume: 322 start-page: 1549 year: 1990 end-page: 1554 ident: CR31 article-title: Platelet hyperreactivity and prognosis in survivors of myocardial infarction publication-title: N Engl J Med doi: 10.1056/NEJM199005313222201 contributor: fullname: Vreeken – volume: 46 start-page: 3 year: 2001 end-page: 26 ident: CR18 article-title: Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings publication-title: Adv Drug Deliv Rev doi: 10.1016/S0169-409X(00)00129-0 contributor: fullname: Feeney – year: 1969 ident: CR27 publication-title: Thin-layer Chromatography doi: 10.1007/978-3-642-88488-7 contributor: fullname: Stahl – volume: 24 start-page: 1139 year: 1981 end-page: 1148 ident: CR19 article-title: Highly selective inhibitors of thromboxane synthetase. 1 Imidazole derivatives publication-title: J Med Chem doi: 10.1021/jm00142a005 contributor: fullname: Nakazawa – volume: 45 start-page: 646 year: 1993 end-page: 649 ident: CR26 article-title: New pyrazolylhydrazone derivatives as inhibitors of platelet aggregation publication-title: J Pharm Pharmacol doi: 10.1111/j.2042-7158.1993.tb05670.x contributor: fullname: Barreiro – ident: 580_CR33 – volume: 46 start-page: 986 year: 2005 ident: 580_CR21 publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2004.08.070 contributor: fullname: PJ Mason – volume: 52 start-page: 161 year: 2001 ident: 580_CR5 publication-title: Annu Rev Med doi: 10.1146/annurev.med.52.1.161 contributor: fullname: JS Bennett – volume: 119 start-page: 299 year: 2007 ident: 580_CR16 publication-title: J Chem Sci doi: 10.1007/s12039-007-0040-6 contributor: fullname: C Jyothi – volume: 23 start-page: 1578 year: 1958 ident: 580_CR9 publication-title: J Org Chem doi: 10.1021/jo01104a623 contributor: fullname: CC Chu – volume: 110 start-page: 281 year: 2003 ident: 580_CR24 publication-title: Thromb Res doi: 10.1016/S0049-3848(03)00382-7 contributor: fullname: P Patrignani – volume: 24 start-page: 1149 year: 1981 ident: 580_CR29 publication-title: J Med Chem doi: 10.1021/jm00142a006 contributor: fullname: T Tanouchi – volume: 186 start-page: 2021 year: 2011 ident: 580_CR3 publication-title: Phosphorus Sulfur and Silicon Relat Elem doi: 10.1080/10426507.2010.550268 contributor: fullname: PV Badadhe – volume: 7 start-page: 337 year: 2009 ident: 580_CR1 publication-title: Cent Eur J Chem doi: 10.2478/s11532-009-0023-1 contributor: fullname: O Algul – volume: 326 start-page: 242 year: 1992 ident: 580_CR14 publication-title: N Engl J Med doi: 10.1056/NEJM199201233260406 contributor: fullname: V Fuster – volume: 10 start-page: 1497 year: 2005 ident: 580_CR30 publication-title: Drug Discov Today doi: 10.1016/S1359-6446(05)03584-1 contributor: fullname: IV Tetko – volume: 2 start-page: 775 year: 2003 ident: 580_CR15 publication-title: Nat Rev Drug Discov doi: 10.1038/nrd1198 contributor: fullname: SP Jackson – volume: 50 start-page: 7 year: 1995 ident: 580_CR25 publication-title: Drugs doi: 10.2165/00003495-199550010-00002 contributor: fullname: K Schros – volume: 43 start-page: 3714 year: 2000 ident: 580_CR12 publication-title: J Med Chem doi: 10.1021/jm000942e contributor: fullname: P Ertl – volume: 12 start-page: 197 year: 2001 ident: 580_CR28 publication-title: Platelets doi: 10.1080/09537100120058739 contributor: fullname: F Storey – volume: 53 start-page: 363 year: 1985 ident: 580_CR10 publication-title: Br Heart J doi: 10.1136/hrt.53.4.363 contributor: fullname: MJ Davis – volume: 14 start-page: 1595 year: 2009 ident: 580_CR13 publication-title: Molecules doi: 10.3390/molecules14041595 contributor: fullname: J Escalante – ident: 580_CR32 – volume: 137 start-page: 571 year: 1987 ident: 580_CR20 publication-title: J Urol doi: 10.1016/S0022-5347(17)44108-5 contributor: fullname: MH Loo – volume: 11 start-page: 1243 year: 2004 ident: 580_CR11 publication-title: Curr Med Chem doi: 10.2174/0929867043365279 contributor: fullname: X Leval De – volume: 36 start-page: 367 year: 2012 ident: 580_CR4 publication-title: Turk J Chem contributor: fullname: S Baytas – volume: 88 start-page: 711 year: 2002 ident: 580_CR22 publication-title: Thromb Haemost doi: 10.1055/s-0037-1613290 contributor: fullname: SA McKee – volume: 24 start-page: 1139 year: 1981 ident: 580_CR19 publication-title: J Med Chem doi: 10.1021/jm00142a005 contributor: fullname: K Lizuka – volume: 28 start-page: 273 year: 1989 ident: 580_CR2 publication-title: Prog Lipid Res doi: 10.1016/0163-7827(89)90002-7 contributor: fullname: H Arita – volume: 55 start-page: 69 year: 1986 ident: 580_CR23 publication-title: Annu Rev Biochem doi: 10.1146/annurev.bi.55.070186.000441 contributor: fullname: P Needleman – volume: 322 start-page: 1549 year: 1990 ident: 580_CR31 publication-title: N Engl J Med doi: 10.1056/NEJM199005313222201 contributor: fullname: MD Trip – volume: 104 start-page: 2746 year: 2001 ident: 580_CR34 publication-title: Circulation doi: 10.1161/hc4601.099487 contributor: fullname: S Yusuf – volume: 46 start-page: 3 year: 2001 ident: 580_CR18 publication-title: Adv Drug Deliv Rev doi: 10.1016/S0169-409X(00)00129-0 contributor: fullname: CA Lipinski – volume-title: Thin-layer Chromatography year: 1969 ident: 580_CR27 doi: 10.1007/978-3-642-88488-7 contributor: fullname: E Stahl – volume: 1 start-page: 192 year: 1999 ident: 580_CR6 publication-title: Curr Cardiol Rep doi: 10.1007/s11886-999-0022-z contributor: fullname: PB Berger – volume: 17 start-page: 359 year: 2008 ident: 580_CR17 publication-title: Indian J Heterocycl Chem contributor: fullname: B Kalluraya – volume: 26 start-page: 331 year: 2005 ident: 580_CR8 publication-title: Endocr Rev doi: 10.1210/er.2004-0015 contributor: fullname: RW Brueggemeier – volume: 168 start-page: 178 year: 1963 ident: 580_CR7 publication-title: J Physiol doi: 10.1113/jphysiol.1963.sp007185 contributor: fullname: G Born – volume: 45 start-page: 646 year: 1993 ident: 580_CR26 publication-title: J Pharm Pharmacol doi: 10.1111/j.2042-7158.1993.tb05670.x contributor: fullname: IAFB Silveira |
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E
)-3-[3-(pyridin-4-yl)-1-phenyl-1
H
-pyrazole-4-yl]acryl amides were evaluated for their antiplatelet activities. Compounds
4o
and
4r
were found as active... |
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| SubjectTerms | Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Original Research Pharmacology/Toxicology |
| Title | Novel 1,3-diarylpyrazole acrylamides: synthesis, antiplatelet activity screening, and in silico evaluation studies |
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