Malignant hyperthermia in a child with Duchenne muscular dystrophy

Patients with Duchenne muscular dystrophy (DMD) are susceptible to numerous adverse intraoperative and postoperative side effects of anesthetic agents. These include: hyperthermia and hyperkalemia,1,2 systemic acidosis,3 cardiac abnormalities (tachycardia, arrhythmia, arrest),2-5 rhabdomyolysis,2-6...

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Bibliographic Details
Published in:	Pediatrics (Evanston) Vol. 71; no. 1; pp. 118 - 119
Main Authors:	Kelfer, H M, Singer, W D, Reynolds, R N
Format:	Journal Article
Language:	English
Published:	United States 01-01-1983
Subjects:	Child, Preschool Dantrolene - therapeutic use Humans Male Malignant Hyperthermia - complications Muscular Dystrophies - complications Muscular Dystrophies - genetics Preanesthetic Medication
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Summary:	Patients with Duchenne muscular dystrophy (DMD) are susceptible to numerous adverse intraoperative and postoperative side effects of anesthetic agents. These include: hyperthermia and hyperkalemia,1,2 systemic acidosis,3 cardiac abnormalities (tachycardia, arrhythmia, arrest),2-5 rhabdomyolysis,2-6 as well as death.2,5 These clinical and laboratory findings are similar to those associated with malignant hyperthermia (MH).7,8 Until this time no one has confirmed the association of MH, as reflected by these clinical phenomena, in a patient with DMD. We present a patient who manifested many features of MH immediately following confirmatory muscle biopsy for DMD under general anesthesia. In vitro response to testing of a muscle biopsy specimen was consistent with a diagnosis of malignant hyperthermia.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0031-4005 1098-4275
DOI:	10.1542/peds.71.1.118