Brain MRI-findings in Ph - negative myeloproliferative disorders

• Published in: Terapevtic̆eskii arhiv Vol. 91; no. 7; pp. 29 - 34
• Main Authors: Tanashyan, M M, Melikyan, A L, Kuznetsova, P I, Raskurazhev, A A, Shabalina, A A, Konovalov, R N
• Format: Journal Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 15-07-2019
• Subjects: cerebrovascular disease; focal cerebral lesions; hematology; hemorheology; hemostasis; myeloproliferative diseases
• ISSN: 0040-3660; 2309-5342
• DOI: 10.26442/00403660.2019.07.000329

Myeloproliferative disorders (MPD) are accompanied by a high proportion of thrombotic complications, which may lead to cerebrovascular disease (CVD). Aim. To describe MRI-findings in patients with Ph - negative MPD and evaluate any cerebrovascular disease. Materials and methods. We included 104 patients with Ph - negative MPD (age varied between 20 and 58) with clinical correlates of cerebrovascular pathology. Results. Brain MRI showed post - stroke lesions in 20% of patients (7 hemispheric infarcts due to thrombotic occlusion of one of the large cerebral arteries, 14 - cortical infarcts). 37 patients (36%) had vascular cerebral lesions. Cerebral venous sinus thrombosis occurred in 5 patients - in 7% (n=3) of patients with polycythemia vera and 5% (n=2) - in patients with essential thrombocythemia. The incidence of vascular cerebral lesions was associated with higher levels of the following: erythrocyte, platelet count, fibrinogen, and with the decrease in fibrinolytic activity, as well. Conclusion. The pioneering results of the study include the description and analysis of brain MRI-findings in patients with Ph - negative MPD. The underlying mechanisms of cerebrovascular pathology in these patients are associated with certain blood alterations (particularly, hemorheology) which present a major risk factor.