The Excellent Chemical Interaction Properties of Poloxamer and Pullulan with Alpha Mangostin on Amorphous Solid Dispersion System: Molecular Dynamics Simulation

Background: Alpha mangostin (AM) has demonstrated significant potential as an anticancer agent, owing to its potent bioactivity. However, its clinical application is limited by poor solubility, which hampers its bioavailability and effectiveness. Amorphous solid dispersion (ASD) presents a promising...

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Bibliographic Details
Published in:	Polymers Vol. 16; no. 21; p. 3065
Main Authors:	Rusdin, Agus, Muchtaridi, Muchtaridi, Megantara, Sandra, Wardhana, Yoga Windhu, Fakih, Taufik Muhammad, Budiman, Arif
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 31-10-2024 MDPI
Subjects:	alpha mangostin amorphous solid dispersion Bioavailability Breast cancer Cancer Cancer therapies Care and treatment Chemical bonds Comparative analysis Cooling Cooling rate Dynamic structural analysis Effectiveness Hydrogen Hydrogen bonding Ligands molecular dynamic Molecular dynamics Molecular structure Optimization poloxamer Poloxamers Polymers Polysaccharides Prostate Pullulan Simulation Simulation methods Software Solubility Stability Indonesia
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