Enhanced Production of 6-(N-Hydroxyethyl)-Amino-6-Deoxy-α-L-Sorbofuranose by Immobilized Gluconobacter oxydanson Corn Stover with a pH Control Strategy in a Bubble Column Bioreactor

6-( N -Hydroxyethyl)-amino-6-deoxy-α-L-sorbofuranose (6NSL) is a key intermediate in the synthesis of miglitol. Biotransformation of N -2-hydroxyethyl glucamine (NHEG) to 6NSL was performed by immobilized Gluconobacter oxydans , which was prepared by cultivating the cells in a home-made bubble colum...

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Bibliographic Details
Published in:	Applied biochemistry and biotechnology Vol. 188; no. 2; pp. 297 - 309
Main Authors:	Hu, Zhong-Ce, Bu, Jia-Li, Wang, Ru-Yi, Ke, Xia, Zheng, Yu-Guo
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-06-2019 Springer Nature B.V
Subjects:	Aeration Ammonia Ammonium chloride Bacteria Biochemistry Bioreactors Biotechnology Biotransformation Bubble columns Chemistry Chemistry and Materials Science Corn Gluconobacter oxydans Immobilized cells Miglitol pH control pH effects Sodium hydroxide Stover Supplements Hydroxyethyl)-amino-6-deoxy-α-L-sorbofuranose Corn stover Biotransformation Cell immobilization 6- Gluconobacter oxydans 6-(N-Hydroxyethyl)-amino-6-deoxy-α-L-sorbofuranose
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