Characterization of FEN1 gene involved in sensitivity to Sterol Biosynthesis Inhibitors in Saccharomyces cerevisiae

The study of yeast sensitivity to sterols biosynthesis inhibitors led us to clone the FEN1 gene. Strains carrying defective allele of FEN1 gene are resistant to inhibitors of post-squalene biosynthesis steps. Overexpression of this gene causes hypersensitivity to these inhibotors. Other groups have...

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Bibliographic Details
Published in:	Acta botanica gallica Vol. 146; no. 1; pp. 67 - 72
Main Authors:	Joets, Johann, Soustre, Isabelle, Kribii, Rachida, Delourme, Didier, Karst, Francis
Format:	Journal Article
Language:	English
Published:	Châtenay-Malabry Taylor & Francis Group 01-01-1999 Société botanique de France
Subjects:	Biological and medical sciences ELO2 ergosterol ergostérol FEN1 Fundamental and applied biological sciences. Psychology GNS1 Growth, nutrition, metabolism, transports, enzymes. Molecular biology inhibiteur inhibitor L-733,560 levure Microbiology Mycology SRE2 SUR5 YCR34W yeast Fungi Characterization Sensitivity resistance Gene Ascomycetes Biosynthesis Sterol synthesis inhibitor Gene expression Mechanism of action Saccharomyces cerevisiae Thallophyta Sterol
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Summary:	The study of yeast sensitivity to sterols biosynthesis inhibitors led us to clone the FEN1 gene. Strains carrying defective allele of FEN1 gene are resistant to inhibitors of post-squalene biosynthesis steps. Overexpression of this gene causes hypersensitivity to these inhibotors. Other groups have cloned FEN1 gene in different physiological contexts. We present here the chromosomal localisation of FEN 1 at the YCR34W locus and results of investigations devoted to unterstand the function of this gene.
ISSN:	1253-8078 2166-3408
DOI:	10.1080/12538078.1999.10515802