The CD36 scavenger receptor Bez regulates lipid redistribution from fat body to ovaries in Drosophila
Lipid distribution in an organism is mediated by the interplay between lipoprotein particles, lipoprotein receptors and class B scavenger receptors of the CD36 family. CD36 is a multifunctional protein mediating lipid uptake, mobilization and signaling at the plasma membrane and inside of the cell....
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| Published in: | Development (Cambridge) Vol. 151; no. 9 |
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| Format: | Journal Article |
| Language: | English |
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01-05-2024
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| Abstract | Lipid distribution in an organism is mediated by the interplay between lipoprotein particles, lipoprotein receptors and class B scavenger receptors of the CD36 family. CD36 is a multifunctional protein mediating lipid uptake, mobilization and signaling at the plasma membrane and inside of the cell. The CD36 protein family has 14 members in Drosophila melanogaster, which allows for the differentiated analysis of their functions. Here, we unravel a role for the so far uncharacterized scavenger receptor Bez in lipid export from Drosophila adipocytes. Bez shares the lipid binding residue with CD36 and is expressed at the plasma membrane of the embryonic, larval and adult fat body. Bez loss of function lowers the organismal availability of storage lipids and blocks the maturation of egg chambers in ovaries. We demonstrate that Bez interacts with the APOB homolog Lipophorin at the plasma membrane of adipocytes and trace the Bez-dependent transfer of an alkyne-labeled fatty acid from adipocytes to Lipophorin. Our study demonstrates how lipids are distributed by scavenger receptor-lipoprotein interplay and contribute to the metabolic control of development. |
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| AbstractList | Lipid distribution in an organism is mediated by the interplay between lipoprotein particles, lipoprotein receptors and class B scavenger receptors of the CD36 family. CD36 is a multifunctional protein mediating lipid uptake, mobilization and signaling at the plasma membrane and inside of the cell. The CD36 protein family has 14 members in Drosophila melanogaster, which allows for the differentiated analysis of their functions. Here, we unravel a role for the so far uncharacterized scavenger receptor Bez in lipid export from Drosophila adipocytes. Bez shares the lipid binding residue with CD36 and is expressed at the plasma membrane of the embryonic, larval and adult fat body. Bez loss of function lowers the organismal availability of storage lipids and blocks the maturation of egg chambers in ovaries. We demonstrate that Bez interacts with the APOB homolog Lipophorin at the plasma membrane of adipocytes and trace the Bez-dependent transfer of an alkyne-labeled fatty acid from adipocytes to Lipophorin. Our study demonstrates how lipids are distributed by scavenger receptor-lipoprotein interplay and contribute to the metabolic control of development. |
| Author | Bülow, Margret H Odenthal, Johanna Risse, Katharina S Jung, Yerin Carrera, Pilar Kuerschner, Lars |
| Author_xml | – sequence: 1 givenname: Pilar surname: Carrera fullname: Carrera, Pilar organization: Life and Medical Sciences (LIMES), University of Bonn, Carl-Troll-Straße 31, 53115 Bonn, Germany – sequence: 2 givenname: Johanna surname: Odenthal fullname: Odenthal, Johanna organization: Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine, University of Cologne, University Hospital Cologne, 50931 Cologne, Germany – sequence: 3 givenname: Katharina S orcidid: 0009-0002-3207-9991 surname: Risse fullname: Risse, Katharina S organization: Life and Medical Sciences (LIMES), University of Bonn, Carl-Troll-Straße 31, 53115 Bonn, Germany – sequence: 4 givenname: Yerin surname: Jung fullname: Jung, Yerin organization: Life and Medical Sciences (LIMES), University of Bonn, Carl-Troll-Straße 31, 53115 Bonn, Germany – sequence: 5 givenname: Lars orcidid: 0000-0003-4783-0442 surname: Kuerschner fullname: Kuerschner, Lars organization: Life and Medical Sciences (LIMES), University of Bonn, Carl-Troll-Straße 31, 53115 Bonn, Germany – sequence: 6 givenname: Margret H orcidid: 0000-0001-6006-8507 surname: Bülow fullname: Bülow, Margret H organization: Life and Medical Sciences (LIMES), University of Bonn, Carl-Troll-Straße 31, 53115 Bonn, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38713014$$D View this record in MEDLINE/PubMed |
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| Keywords | Scavenger receptor Reproduction Lipids Adipocytes Click chemistry Lipoprotein Drosophila melanogaster |
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| SubjectTerms | Adipocytes - metabolism Animals CD36 Antigens - genetics CD36 Antigens - metabolism Cell Membrane - metabolism Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Fat Body - metabolism Female Lipid Metabolism Lipoproteins - metabolism Ovary - metabolism Receptors, Scavenger - genetics Receptors, Scavenger - metabolism |
| Title | The CD36 scavenger receptor Bez regulates lipid redistribution from fat body to ovaries in Drosophila |
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