Chronic cold stress modulates the function of peritoneal macrophages in vivo

• Published in: Doklady. Biological sciences Vol. 474; no. 1; pp. 129 - 131
• Main Authors: Gein, S. V., Sharav’eva, I. L.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01-05-2017; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Cell Biology; Cold Temperature; Corticosterone; Corticosterone - blood; Evolutionary Biology; Interleukin 1; Interleukin 10; Interleukin-10 - metabolism; Interleukin-1beta - metabolism; Life Sciences; Macrophages; Macrophages, Peritoneal - drug effects; Macrophages, Peritoneal - metabolism; Mice; Naloxone; Naloxone - pharmacology; Opioid receptors; Peritoneum; Plant Sciences; Reactive oxygen species; Reactive Oxygen Species - metabolism; Receptors, Opioid - metabolism; Rodents; Tumor Necrosis Factor-alpha - metabolism; Zymosan - pharmacology
• ISSN: 0012-4966; 1608-3105
• DOI: 10.1134/S0012496617030127

On day 7 of chronic cold stress, concentration of corticosterone in plasma was established to increase, zymosan-induced production of reactive oxygen species was activated, and IL-10 synthesis by macrophages was enhanced regardless of the opiate receptor blockade. Increase in the concentration of corticosterone was independent of the blockade of opioid receptors, whereas the zymosan-induced increase in the production of oxygen radicals and activation of the spontaneous production of IL-10 was blocked in mice by naloxone. Chronic cold stress had no effect on the production of IL-1β and TNF-α.