Genetic Analysis Is Consistent With the Hypothesis That NF1 Limits Myeloid Cell Growth Through p21ras

Children with neurofibromatosis, type 1 (NF-1) are at increased risk of developing malignant myeloid disorders and their bone marrows frequently show loss of the normal allele of the NF1 tumor-suppressor gene. NF1 encodes a protein called neurofibromin, which accelerates guanosine triphosphate (GTP)...

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Bibliographic Details
Published in:	Blood Vol. 84; no. 10; pp. 3435 - 3439
Main Authors:	Kalra, Ruby, Paderanga, Dorothy C., Olson, Kristin, Shannon, Kevin M.
Format:	Journal Article
Language:	English
Published:	Washington, DC Elsevier Inc 15-11-1994 The Americain Society of Hematology
Subjects:	Alleles Amino Acid Sequence Base Sequence Biological and medical sciences Bone Marrow - pathology Child Cloning, Molecular Codon - genetics Exons Genes, Neurofibromatosis 1 Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myeloid, Acute - genetics Medical sciences Molecular Sequence Data Neurofibromin 1 Neurology Oligodeoxyribonucleotides Point Mutation Preleukemia - genetics Protein Biosynthesis Proteins - genetics Proto-Oncogene Proteins p21(ras) - biosynthesis Proto-Oncogene Proteins p21(ras) - metabolism Restriction Mapping Signal Transduction Tumors of the nervous system. Phacomatoses Human Nervous system diseases Phacomatosis Neurofibromatosis Exploration Malignant hemopathy Benign neoplasm Gene expression Myeloid cell Child
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