Structural Characterization and Disulfide Assignment of Spider Peptide Phα1β by Mass Spectrometry

Native Phα1β is a peptide purified from the venom of the armed spider Phoneutria nigriventer that has been shown to have an extensive analgesic effect with fewer side effects than ω-conotoxin MVIIA. Recombinant Phα1β mimics the effects of the native Phα1β. Because of this, it has been suggested that...

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Bibliographic Details
Published in:	Journal of the American Society for Mass Spectrometry Vol. 29; no. 5; pp. 827 - 841
Main Authors:	Wormwood, Kelly L., Ngounou Wetie, Armand Gatien, Gomez, Marcus Vinicius, Ju, Yue, Kowalski, Paul, Mihasan, Marius, Darie, Costel C.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-05-2018 Springer Nature B.V
Subjects:	Amino Acid Sequence Analgesics Analgesics - chemistry Analytical Chemistry Animals Bioinformatics Biotechnology Chemistry Chemistry and Materials Science Cysteine - analysis Disulfides - analysis Focus: 29th Sanibel Conference Ions Linkages Mass spectrometry Organic Chemistry Pain Peptides Peptides - chemistry Peptidomics: Bridging the Gap Between Proteomics and Metabolomics by MS: Research Article Pharmacology Proteomics Scientific imaging Side effects Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectroscopy Spider Venoms - chemistry Spiders - chemistry Structural analysis Tandem Mass Spectrometry - methods Trypsin Venom peptides Mass spectrometry Protein structure Disulfide bridges
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